| Kinesin-3 Family Member KIF1A | |
|---|---|
| Protein Name | Kinesin-3 Family Member KIF1A |
| Gene | KIF1A |
| UniProt ID | Q9Y4D4 |
| PDB Structures | 5WVE |
| Molecular Weight | 192 kDa |
| Subcellular Localization | Axons |
| Protein Family | Kinesin-3 family |
This protein is a member of the kinesin family involved in intracellular transport.
This protein is a member of the kinesin family of motor proteins that transport cargo along microtubules within cells.
Kinesin proteins are essential for neuronal function, transporting synaptic vesicles, proteins, and organelles along axonal and dendritic microtubules.
Kinesin-3 Family Member KIF1A is a 192 kDa protein belonging to the Kinesin-3 family. The protein has distinct structural domains that mediate its function in neuronal survival and signaling.
KIF1A is a monomeric motor protein that transports synaptic vesicle precursors, dense-core vesicles, and mitochondria along axons. It is one of the fastest motor proteins and is crucial for synaptic development and function.
Mutations in KIF1A cause hereditary spastic paraplegia and Charcot-Marie-Tooth disease type 2. These mutations lead to impaired axonal transport and neurodegeneration.
Research is ongoing to develop therapies targeting this protein for neurodegenerative diseases: