Il 6R Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
:: infobox .infobox-protein
| Protein Name | Interleukin-6 Receptor (IL-6R) |
| Gene | IL6R |
| UniProt ID | P08887 |
| Molecular Weight | ~80 kDa (membrane form) |
| Subcellular Localization | Cell membrane, soluble (secreted) |
| Protein Family | Type I cytokine receptor family |
| PDB Structures | 1N2H, 1P9M |
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The Interleukin-6 Receptor (IL-6R) is a cytokine receptor that binds interleukin-6 (IL-6), initiating pro-inflammatory signaling. IL-6R exists in both membrane-bound and soluble forms, allowing IL-6 to act on a wide variety of cells. The IL-6/IL-6R/gp130 signaling axis is a major contributor to chronic neuroinflammation in neurodegenerative diseases.
IL-6R is a type I cytokine receptor:
The receptor also exists as a soluble form (sIL-6R) generated by:
IL-6/IL-6R is elevated in AD:
IL-6/IL-6R signaling in PD:
IL-6R is central to MS pathophysiology:
IL-6R is a successful drug target:
The study of Il 6R Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.