Gria1 Protein (Ampa Receptor 1) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
This page provides comprehensive information about GRIA1 Protein, including its structure, normal function in the nervous system, and its role in neurodegenerative diseases.
:: infobox infobox-protein
!Protein Name | Glutamate Ionotropic Receptor AMPA Type Subunit 1 (GRIA1)
!Gene | GRIA1
!UniProt ID | P42262
!PDB Structure | 4G5F, 5LMP, 6XJN
!Molecular Weight | ~103 kDa
!Subcellular Localization | Postsynaptic membrane
!Protein Family | Ionotropic glutamate receptors, AMPA receptor family
!
GRIA1 (GluA1) is an AMPA receptor subunit with a characteristic ion channel structure:
AMPA receptors are tetramers, typically composed of combinations of GRIA1-4 subunits.
AMPA receptors mediate fast excitatory synaptic transmission:
| Approach | Status | Description |
|---|---|---|
| AMPA Antagonists | Approved | Perampanel for seizures |
| AMPA Modulators | Clinical | CX-516 (CX-516) for cognition |
| Positive Modulators | Preclinical | Ampakines for memory enhancement |
| Gene Therapy | Research | Correct GRIA1 mutations |
Traynelis SF, et al. (2010) "Glutamate receptor ion channels: structure, regulation, and function." Pharmacol Rev 62:405-496. DOI:10.1124/pr.109.002451
Huganir RL, Nicoll RA. (2013) "AMPARs and synaptic plasticity: the last 25 years." Neuron 80:704-717. DOI:10.1016/j.neuron.2013.10.025
Twomey EC, et al. (2017) "Structure and mechanism of AMPA receptor." Curr Opin Struct Biol 45:68-74.
Henley JM, Wilkinson KA. (2016) "Synaptic AMPA receptor trafficking in the normal and diseased CNS." Nat Rev Neurosci 17:597-610.
The study of Gria1 Protein (Ampa Receptor 1) has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.