Fzd7 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| FZD7 Protein | |
|---|---|
| Frizzled Class Receptor 7 | |
| Gene | FZD7 |
| UniProt ID | O75084 |
| PDB ID | 6TYW |
| Molecular Weight | 64,100 Da |
| Subcellular Localization | Plasma membrane |
| Protein Family | Frizzled receptor family |
FZD7 (Frizzled-7) is a seven-transmembrane receptor that primarily activates canonical Wnt/β-catenin signaling. It is highly expressed in neural stem cells and plays critical roles in embryonic development, stem cell maintenance, and tissue morphogenesis.
FZD7 activates β-catenin pathway:
Maintains neural stem cell population:
FZD7 in AD:
FZD7 overexpressed in:
FZD7 interacts with:
The study of Fzd7 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.