Fis1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
FIS1 (Fission 1 Protein) is a small mitochondrial outer membrane protein that plays a critical role in mitochondrial fission. FIS1 recruits the dynamin-related protein Drp1 to the mitochondrial surface to mediate membrane scission. It is essential for mitochondrial quality control, cell survival, and is implicated in various neurodegenerative diseases where mitochondrial dynamics are disrupted [1][2].
| Attribute | Value |
|---|---|
| Gene Symbol | FIS1 |
| Protein Name | Fission 1 Protein |
| Alternative Names | FIS1, TTC4 |
| UniProt ID | Q9NY3I |
| Molecular Weight | ~17 kDa |
| Protein Family | FIS1 family |
| Subcellular Localization | Mitochondrial outer membrane |
FIS1 has a simple structure:
FIS1 forms homodimers and higher-order oligomers to function [3].
FIS1 mediates fission:
FIS1 regulates:
In neurons:
FIS1 is altered in AD:
Targeting FIS1:
The study of Fis1 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
James DI, et al. (2003). "FIS1 defines mitochondrial fission." Exp Cell Res. ↩︎
Stoops EH, et al. (2008). "FIS1 function in mitochondrial fission." Biochim Biophys Acta. ↩︎
Liu J, et al. (2009). "FIS1 structure and oligomerization." J Mol Biol. ↩︎
Cheng A, et al. (2010). "FIS1 in neuronal mitochondria." J Neurosci. ↩︎
Liu J, et al. (2012). "FIS1 and neuroprotection." Cell Death Differ. ↩︎