Dram1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
DRAM1 is a lysosomal membrane protein that serves as a key modulator of autophagy, the cellular process for degrading and recycling damaged proteins and organelles. It plays critical roles in neuronal survival under proteotoxic stress conditions.
DRAM1 Protein (DNA Damage Regulated Autophagy Modulator 1) is a transmembrane protein localized to the lysosome and endoplasmic reticulum. It functions as a key regulator of autophagy, particularly in response to cellular stress and DNA damage. DRAM1 protein is implicated in the pathogenesis of neurodegenerative diseases through its role in autophagic-lysosomal pathway dysfunction.
| Property | Value |
|---|---|
| Protein Name | DNA Damage Regulated Autophagy Modulator 1 (DRAM1) |
| Gene | DRAM1 |
| UniProt ID | Q8WXX5 |
| Molecular Weight | 37 kDa |
| Subcellular Localization | Lysosomal membrane |
| Protein Family | DRAM family |
| Compound | Mechanism | Status |
|---|---|---|
| Rapamycin | mTOR inhibition | Approved (organ transplant) |
| Trehalose | mTOR-independent | Research |
| Metformin | AMPK activation | Approved (diabetes) |
| Lithium | mTOR-independent | Research |
11 function. DRAM - Nat Cell Biol (2006) - PMID:16543938
2. DRAM1 and autophagy - Autophagy (2010) - PMID:20404483
3. DRAM1 in neurodegeneration - J Neurosci (2015) - PMID:25632056
The study of Dram1 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.