| DJ-1 | |
|---|---|
| Protein DJ-1 / PARK7 | |
| Protein Name | Protein DJ-1 |
| Gene | PARK7 |
| UniProt ID | Q99497 |
| PDB IDs | 1PDV, 1X4X, 2MO3, 5D8J |
| Molecular Weight | ~20 kDa |
| Subcellular Localization | Cytosol, nucleus, mitochondria |
| Protein Family | DJ-1 family, ThiJ/PfpI superfamily |
Dj 1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
DJ-1 (encoded by the PARK7 gene) is a multifunctional protein involved in oxidative stress response, mitochondrial function, and transcriptional regulation. Mutations in DJ-1 cause early-onset autosomal recessive Parkinson's disease.
DJ-1 is a homodimeric protein with:
The protein undergoes oxidative modifications at C106 under stress conditions.
DJ-1 has diverse cellular functions:
Loss-of-function mutations in DJ-1 cause early-onset Parkinson's disease (PARK7):
The study of Dj 1 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.