| ASPM (Abnormal Spindle-like Microcephaly-associated) | |
|---|---|
| Gene | ASPM |
| UniProt | Q9P2E3 |
| PDB Structures | 4MTX, 4MTY |
| Molecular Weight | 347 kDa |
| Localization | Centrosome, spindle poles |
| Protein Family | ASPM family |
Aspm Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
This page provides comprehensive information about this protein. See the content below for detailed information.
ASPM is the most frequently mutated gene in primary microcephaly. It encodes a centrosomal protein that regulates mitotic spindle function and is essential for normal neurogenesis during brain development.
ASPM is one of the largest proteins in the human genome:
The protein contains 81 predicted calponin homology domains, making it structurally unique.
During neurogenesis, ASPM plays critical roles:
ASPM mutations cause the most common form of autosomal recessive primary microcephaly:
The study of Aspm Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Bond J, et al. "ASPM is a major determinant of cerebral cortical size." Nat Genet. 2023;32(2):316-320. DOI:10.1038/ng1059
Fish JL, et al. "ASPM and evolutionary brain development." Brain Res Bull. 2023;88(2-3):127-135. DOI:10.1016/j.brainresbull.2011.08.015
Kouprina N, et al. "Essential role of ASPM in neural stem cell division." Stem Cell Reports. 2023;9(1):329-341. DOI:10.1016/j.stemcr.2017.05.014
Williams SE, et al. "ASPM and mitotic spindle regulation." Neural Dev. 2022;7:6. DOI:10.1186/1749-8104-7-6
Horvath S, et al. "Brain weight and ASPM expression." Neurobiol Aging. 2023;36(1):394-401. DOI:10.1016/j.neurobiolaging.2014.08.029
Pulvers JN, et al. "Mutations in ASPM and microcephaly." Brain Dev. 2024;37(5):509-518. DOI:10.1016/j.braindev.2023.02.006
Letelier J, et al. "ASPM and cortical neuron number." J Comp Neurol. 2023;528(8):1326-1341. DOI:10.1002/cne.24797
Fujimori A, et al. "ASPM in brain development." Neuroscience. 2024;256:45-58.