Adenosine A3 Receptor Protein is involved in circadian rhythm regulation and has been implicated in neurodegenerative diseases. This page provides information about its structure, function, and role in neurodegeneration.
Adenosine A3 Receptor Protein plays a critical role in the molecular circadian clock and its dysregulation may contribute to neurodegeneration.
| Adenosine A3 Receptor Protein | |
|---|---|
| Protein Name | Adenosine A3 Receptor Protein |
| Gene | ADORA3 |
| UniProt ID | P0DP24 |
| Molecular Weight | 36 kDa |
| Subcellular Localization | Cell membrane |
| Protein Family | G protein-coupled receptor |
Describe the protein structure including domains and post-translational modifications.
ADORA3 is an adenosine receptor that couples to Gi proteins, inhibiting adenylate cyclase. It modulates immune cell function and has anti-inflammatory properties.
ADORA3 activation reduces neuroinflammation in models of Alzheimer's and Parkinson's disease. It protects against ischemic injury.
ADORA3 agonists are being investigated for neuroinflammatory disorders. MRS5980 and other selective agonists show promise.