This hypothesis proposes that Pathologic synergy occurring in the amygdala between amyloid plaques and Tau/NFT may facilitate the transition from primary age-related tauopathy (PART) to more severe AD.
Type: Causal Chain
Confidence: Proposed
Related Diseases: Alzheimer disease, PART
Data from UK-ADC cohort shows early convergence of substantial densities of both neuritic amyloid plaques and NFTs in the amygdala, representing a key transition point from PART to widespread tauopathy of AD
Ab, Tau, NFT, amygdala, Braak NFT stages
This hypothesis has been proposed but requires further validation.