Tial1 Protein (Tia1 Cytotoxic Granule Associated Rna Binding Protein) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
:: infobox .infobox-protein
| TIAL1 Protein (TIA1 Cytotoxic Granule-Associated RNA Binding Protein) | |
|---|---|
| Gene | TIAL1 |
| UniProt | Q9YB75 |
| Molecular Weight | ~52 kDa |
| Subcellular Localization | Cytoplasm, stress granules |
| Protein Family | TIA1 family (RNA-binding proteins) |
| Aliases | TIAL1, TIAR |
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TIAL1 (TIA1 Cytotoxic Granule-Associated RNA Binding Protein) is a protein involved in various cellular processes. This protein plays important roles in cellular signaling and function.
TIAL1 is an RNA-binding protein containing three RNA recognition motifs (RRMs). The protein is approximately 420 amino acids and localizes to stress granules under cellular stress conditions. It contains a C-terminal prion-related domain that promotes phase separation.
TIAL1 regulates RNA metabolism:
TIAL1 is implicated in ALS pathogenesis:
TIAL1 dysregulation affects cell survival and proliferation in various cancers.
TIAL1 modulators are being explored for:
The study of Tial1 Protein (Tia1 Cytotoxic Granule Associated Rna Binding Protein) has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.