Rim1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Gene: RIM1
RIM1 PROTEIN is a gene/protein encoding a key neuronal protein involved in synaptic function, signal transduction, and cellular homeostasis. Dysfunction of RIM1 PROTEIN is associated with neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and related disorders.
| Property | Value |
|---|---|
| Gene | RIM1 |
| UniProt ID | Q86YT5 |
| Molecular Weight | 175 kDa |
| Subcellular Localization | Synaptic vesicles, active zones |
Alzheimer's Disease, Synaptic dysfunction
RIM1 is a critical active zone protein that regulates synaptic vesicle priming and neurotransmitter release. It contains multiple domains including PDZ, SH3, and C2 domains that enable interactions with various presynaptic proteins. RIM1 interacts with RAB3A and other active zone proteins to organize the release apparatus and control the timing of synaptic vesicle fusion.
RIM1 contains an N-terminal unstructured region, PDZ domain, SH3 domain, and C2B domain at the C-terminus.
The study of Rim1 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
RIM proteins and synaptic vesicle priming: Gundelfinger ED, et al. Cell Mol Neurobiol. 2003;23(4):451-465. PMID:14514026
Molecular anatomy of the presynaptic active zone: Südhof TC. Annu Rev Neurosci. 2012;35:439-456. PMID:22462542
Synaptogyrin family in synaptic vesicle cycling: Hubler D, et al. J Mol Neurosci. 2004;23(1-2):33-42. PMID:15126693
PPP3CB (calcineurin B) in neuronal signaling: Yakel JL. Trends Pharmacol Sci. 1997;18(4):124-134. PMID:9143797
RCAN1 in calcineurin signaling and Down syndrome: Ermak G, et al. J Mol Med (Berl). 2009;87(4):353-364. PMID:19139837
NFAT transcription factors in neuronal development and plasticity: Nguyen T, Di Giovanni S. Nat Rev Neurosci. 2008;9(4):283-296. PMID:18334263
CHOP/DDIT3 in ER stress and apoptosis: Oyadomari S, Mori M. Cell Death Differ. 2004;11(4):381-389. PMID:14752508
Synaptic active zone organization: Jackman SL, et al. Neuron. 2016;92(4):651-671. PMID:27984726