Post-traumatic stress disorder (PTSD) is a trauma-related psychiatric disorder characterized by intrusive recollection, avoidance, negative mood and cognition, and persistent hyperarousal after exposure to severe stress.[1][2] It is relevant to NeuroWiki because amygdala, brainstem, stress-axis, and neuromodulatory circuit pages frequently reference PTSD as a systems-level consequence of altered threat processing.
PTSD is strongly linked to altered fear conditioning, dysregulated hypothalamic-pituitary-adrenal axis signaling, and abnormal amygdala-prefrontal-hippocampal interactions.[2:1] Those same circuit motifs are useful comparison points for understanding neuropsychiatric symptoms in neurodegenerative disease.
Prevalence of post-traumatic stress disorder in the United States: a systematic literature review. Current Medical Research and Opinion (2021). ↩︎
Post-traumatic Stress Disorder: A Narrative Review of Pharmacological and Psychotherapeutic Interventions. Cureus (2023). ↩︎ ↩︎