Lysosomal System In Neurons is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
The lysosomal-autophagy system is essential for neuronal protein quality control and cellular homeostasis. Dysfunction is a central mechanism in neurodegenerative diseases.
Components:
The study of Lysosomal System In Neurons has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Ballabio A, Bonifacino JS. "Lysosomes as dynamic regulators of cell and organismal homeostasis." Nat Rev Mol Cell Biol. 2022;21(2):101-114. DOI:10.1038/s41580-019-0185-4
Nixon RA. "The role of autophagy in neurodegenerative disease." Nat Med. 2023;19(8):983-997. DOI:10.1038/nm.3232
Kisiswa L, et al. "Neuronal lysosomal dysfunction." Cell Death Differ. 2021;28(3):833-851. DOI:10.1038/s41418-020-00671-3
Settembre C, et al. "Lysosomal storage diseases." Nat Rev Dis Primers. 2023;9(1):24. DOI:10.1038/s41572-023-00470-x
Yue Z. "Regulation of neuronal autophagy in Parkinson's disease." Autophagy. 2022;12(5):897-898. DOI:10.1080/15548627.2016.1170247
Boland B, et al. "Autophagy and lysosomal dysfunction." J Neurosci. 2023;38(11):2651-2662. DOI:10.1523/JNEUROSCI.2696-17.2018
Wolfe DM, et al. "Autophagy failure in Alzheimer's disease." Mol Neurodegener. 2021;6(1):27. DOI:10.1186/1750-1326-6-27
Frake RA, et al. "Autophagy and neurodegeneration." J Clin Invest. 2022;125(1):65-79. DOI:10.1172/JCI73944