5-HT3 is the only ionotropic serotonin receptor, mediating fast excitatory signaling.
| Property |
Value |
| Category |
Ionotropic Serotonin Receptors |
| Location |
Area postrema, Entorhinal cortex |
| Receptor Type |
5-HT3 |
| Signaling |
Ligand-gated ion channel |
- Family: Cys-loop
- Pentameric: 5-HT3A/B/C
- Ion channel: Permeable to Na+, K+, Ca2+
###Area postrema**: Distribution
- ** Vomiting
- Enteric: Gut motility
- Brain: Limbic
- Vomiting: Area postrema
- Antiemetics: 5-HT3 antagonists
- Chemotherapy: Acute nausea
- Nociception: 5-HT3
- Visceral pain: Gut
- Analgesic: Potential
- Ondansetron: 5-HT3 antagonist
- Chemotherapy: First-line
- Post-operative: Prevention
- 5-HT3: Gut motility
- Alosetron: IBS-D
- Therapeutic: Targeting
- Hoyer. 5-HT3 receptor (1994)
- Barnes. 5-HT3 pharmacology (2009)