5-HT1A receptors are widespread autoreceptors and heteroreceptors modulating serotonin signaling.
| Property |
Value |
| Category |
Serotonin Receptor Neurons |
| Location |
Raphe nuclei, Hippocampus, Cortex |
| Receptor Type |
5-HT1A |
| Signaling |
Gi-coupled, inhibitory |
- Family: 5-HT1 (Gi-coupled)
- Isoforms: Multiple variants
- Dimerization: Functional significance
- Raphe nuclei: Cell bodies
- Soma: Somatodendritic localization
- Negative feedback: Autoregulation
- Hippocampus: CA1, dentate gyrus
- Cortex: Layer V pyramidal cells
- Amygdala: Stress circuits
- Gi protein: Inhibits adenylate cyclase
- cAMP: Decreased
- MAPK: Activation via beta-arrestin
- Hyperpolarization: K+ channels
- Reduced firing: Raphe neurons
- Modulation: Synaptic plasticity
- 5-HT1A agonists: Anxiolytic effects
- Buspirone: Partial agonist
- SSRI effects: 5-HT1A desensitization
- 5-HT1A: Anxiolytic target
- Azapirones: 5-HT1A agonists
- Stress response: 5-HT1A modulation
- Barnes. 5-HT1A receptors (1999)
- Carver. 5-HT1A and depression (2006)