mGluR7 is a group III metabotropic glutamate receptor with high affinity for glutamate, acting as a synaptic filter.
| Property |
Value |
| Category |
Glutamate Receptor Neurons |
| Location |
Cortex, Hippocampus, Amygdala |
| Receptor Type |
mGluR7 (GRM7) |
| Signaling |
Gi-coupled, inhibitory |
- Family: Group III mGluRs
- G protein: Gi/o
- High affinity: nM range glutamate
- Hippocampus: CA3, dentate gyrus
- Cortex: Layer 2/3, 5
- Amygdala: Central nucleus
- High affinity: Detects low glutamate
- Phasic vs tonic: Different activation
- Activity-dependent: Modulation
- Anxiety: Amygdala function
- Memory: Hippocampal plasticity
- Seizure susceptibility: Role unclear
- mGluR7: Seizure protection
- Anticonvulsant: Potential target
- Therapeutic: ADX71743
- mGluR7: Mood regulation
- Antidepressant: Potential
- Therapeutic: Targeting
- Bertaso et al., mGluR7 in synaptic transmission (2010)
- Palazzo et al., mGluR7 as therapeutic target (2016)