mGluR1 is a group I metabotropic glutamate receptor involved in synaptic plasticity and excitotoxicity.
| Property |
Value |
| Category |
Glutamate Receptor Neurons |
| Location |
Cerebellum, Hippocampus, Cortex |
| Receptor Type |
mGluR1 (GRM1) |
| Signaling |
Gq-coupled, phospholipase C activation |
- Family: Group I mGluRs (mGluR1, mGluR5)
- G protein: Gq/11
- PLC activation: Increases IP3/DAG
- Cerebellum: Purkinje cells (high)
- Hippocampus: CA1, dentate gyrus
- Cortex: Layer 2/3 pyramidal neurons
- LTD: Long-term depression
- Motor learning: Cerebellar function
- Memory: Hippocampal plasticity
- Calcium influx: Via TRPC1 channels
- Neurodegeneration: Excessive activation
- Therapeutic: mGluR1 antagonists
- mGluR1: Mutations cause ataxia
- Cerebellar degeneration: Loss of Purkinje cells
- Therapeutic: Targeting mGluR1
- mGluR1: Altered expression
- Synaptic dysfunction: Role unclear
- Therapeutic: Modulation
- Ferraguti et al., mGluR1 in cerebellar LTD (2008)
- Nicoletti et al., Group I mGluRs in neurodegeneration (2011)