mGluR4 is a group III metabotropic glutamate receptor involved in motor control and synaptic plasticity.
| Property |
Value |
| Category |
Glutamate Receptor Neurons |
| Location |
Basal ganglia, Cerebellum, Cortex |
| Receptor Type |
mGluR4 (GRM4) |
| Signaling |
Gi-coupled, inhibitory |
- Family: Group III mGluRs
- G protein: Gi/o
- Localization: Presynaptic terminals
- Basal ganglia: Striatum, GPi, SNr
- Cerebellum: Granule cells
- Cortex: Interneurons
- Basal ganglia: Motor learning
- Parkinson's: Therapeutic target
- Motor coordination: Cerebellar function
- Presynaptic inhibition: Reduces release
- Short-term plasticity: Modulation
- Network oscillations: Role unclear
- mGluR4 agonists: Anti-parkinsonian
- Dyskinesia: Reduction potential
- Therapeutic: PHCCC, LSP1-1
- mGluR4: Cerebellar dysfunction
- Motor coordination: Impaired
- Therapeutic: Targeting mGluR4
- Marino et al., mGluR4 in PD (2005)
- Valenti et al., mGluR4 neuroprotection (2003)