mGluR3 is a group II metabotropic receptor expressed on neurons and glia with modulatory functions.
| Property |
Value |
| Category |
Glutamate Receptor Neurons |
| Location |
Cortex, Hippocampus, Thalamus |
| Receptor Type |
mGluR3 (GRM3) |
| Signaling |
Gi-coupled, inhibitory |
- Family: Group II mGluRs
- G protein: Gi/o
- Expression: Neurons and glia
- Cortex: Pyramidal cells
- Hippocampus: All regions
- Thalamus: Relay neurons
- Presynaptic: Inhibits release
- Postsynaptic: Hyperpolarization
- Astrocyte signaling: Glial modulation
- Growth factor: Increases BDNF
- Anti-inflammatory: Glial modulation
- Anti-excitotoxic: Protective effects
- GRM3 gene: Risk factor
- Cognitive deficits: Working memory
- Therapeutic: mGluR3 targeting
- mGluR3: Motor function
- Basal ganglia: Modulation
- Therapeutic: Potential target
- Schoepp et al., mGluR2/3 pharmacology (2003)
- Corti et al., mGluR3 in CNS (2007)