mGluR2 is a group II metabotropic glutamate receptor with neuroprotective properties.
| Property |
Value |
| Category |
Glutamate Receptor Neurons |
| Location |
Cortex, Hippocampus, Amygdala |
| Receptor Type |
mGluR2 (GRM2) |
| Signaling |
Gi-coupled, inhibitory |
- Family: Group II mGluRs (mGluR2, mGluR3)
- G protein: Gi/o
- cAMP: Decreases cAMP
- Cortex: Pyramidal neurons
- Hippocampus: CA3, dentate gyrus
- Amygdala: Interneurons
- Presynaptic inhibition: Reduces glutamate release
- cAMP modulation: Inhibits adenylate cyclase
- Anti-excitotoxic: Protective in ischemia
- mGluR2: Schizophrenia target
- Anxiolytic: Anxiety modulation
- Antidepressant: Therapeutic potential
- mGluR2/3 agonists: Clinical trials
- Psychosis: Glutamate hypothesis
- Therapeutic: LY379268, pomaglumetad
- Neuroprotection: Amyloid toxicity
- Synaptic function: Preservation
- Therapeutic: mGluR2 modulators
- Conn et al., Group II mGluR therapeutics (2009)
- Nicoletti et al., mGluR2 in neuroprotection (2015)