5-HT7 is an excitatory serotonin receptor involved in mood, sleep, and circadian rhythms.
| Property |
Value |
| Category |
Serotonin Receptor Neurons |
| Location |
Thalamus, Hypothalamus, Hippocampus |
| Receptor Type |
5-HT7 |
| Signaling |
Gs-coupled, excitatory |
- Family: 5-HT7A, 7B, 7C
- G protein: Gs
- cAMP: Increases
- Thalamus: Sensory nuclei
- Hypothalamus: Suprachiasmatic
- Hippocampus: CA1, CA3
- SCN: Entrainment
- Light signaling: Mediates
- Sleep: Phase shifting
- Antidepressant: Rapid effects
- Anxiety: Modulation
- Thermoregulation: Hypothalamic
- 5-HT7: Antidepressant target
- SB-269970: Research tool
- Therapeutic: AS-19
- 5-HT7: Vasodilation
- Pain signaling: Role
- Therapeutic: Targeting
- Hedlund, 5-HT7 in mood (2005)
- Guscott et al., 5-HT7 in CNS (2005)