5-HT4 receptors are excitatory serotonin receptors involved in memory and mood.
| Property |
Value |
| Category |
Serotonin Receptor Neurons |
| Location |
Hippocampus, Cortex, Striatum |
| Receptor Type |
5-HT4 |
| Signaling |
Gs-coupled, excitatory |
- Family: 5-HT4-7
- G protein: Gs/olf
- cAMP: Increases
- Hippocampus: CA1, dentate gyrus
- Cortex: Pyramidal cells
- Striatum: Medium spiny neurons
- Hippocampal plasticity: Facilitation
- Learning: Enhanced
- ** consolidation**: Role in memory
- Antidepressant: Rapid effects
- Anxiety: Anxiolytic
- Reward: Mesolimbic modulation
- 5-HT4: Memory enhancement
- Amyloid: Interactions
- Therapeutic: PRX-3140
- 5-HT4 agonists: Antidepressant
- Fast-acting: Potential
- Therapeutic: Targeting
- Bockaert et al., 5-HT4 receptors (2004)
- Mnie-Filali et al., 5-HT4 in depression (2007)