| Neil W. Buckholtz | |
|---|---|
| Photo placeholder | |
| Affiliations | NIH NIA |
| Country | USA |
| H-index | 80 |
| Research Focus | Alzheimer's Disease |
| Mechanisms | Funding, Research coordination |
Neil W. Buckholtz is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Buckholtz has developed research programs that bridge basic neuroscience, translational biomarker work, and clinical interpretation. Across appointments at NIH and NIA, their group has helped define how mechanistic discoveries are converted into robust disease models and clinically actionable hypotheses.
The laboratory's approach combines rigorous experimental design with broad collaboration across disease-focused teams. This includes hypothesis-driven studies, replication across independent cohorts, and careful interpretation of effect sizes, heterogeneity, and confounding factors that often complicate neurodegeneration research.
The publication portfolio is being expanded from primary literature databases, with emphasis on high-impact studies and longitudinal research programs.
Their program contributes to translational and mechanistic work in [Alzheimer's disease--TEMP--/diseases)--FIX--.
The lab emphasizes Funding to connect molecular findings with patient outcomes. The lab emphasizes Research coordination to connect molecular findings with patient outcomes.
These efforts support clearer disease taxonomy, stronger biomarker validation pipelines, and prioritization of therapeutic targets with human biological relevance. The work also contributes to cross-disease comparisons that reveal shared pathways and disease-specific vulnerabilities.
Current priorities in Buckholtz's research ecosystem include improving reproducibility across cohorts, integrating multi-omic and longitudinal clinical datasets, and clarifying which biological signals are most predictive of near-term progression and treatment response. A recurring challenge across neurodegeneration is separating causal drivers from downstream correlates, especially when molecular pathology and clinical symptoms evolve over long time horizons.
Another central objective is translation: defining how mechanistic discoveries can be converted into practical diagnostics and intervention strategies. This includes identifying robust stratification markers, benchmarking assays across sites, and aligning trial endpoints with biologically meaningful changes rather than only late-stage clinical decline.
Wang L et al.. "Dynamic proportional loss of functional connectivity revealed change of left superior frontal gyrus in subjective cognitive decline: an explanatory study based on Chinese and Western cohorts." GeroScience (2025). DOI
Hodes RJ, Buckholtz N. "Accelerating Medicines Partnership: Alzheimer's Disease (AMP-AD) Knowledge Portal Aids Alzheimer's Drug Discovery through Open Data Sharing." Expert opinion on therapeutic targets (2016). DOI
Jones-Davis DM, Buckholtz N. "The impact of the Alzheimer's Disease Neuroimaging Initiative 2: What role do public-private partnerships have in pushing the boundaries of clinical and basic science research on Alzheimer's disease?." Alzheimers Dement (2015). DOI
Morrison-Bogorad M, Phelps C, Buckholtz N. "Alzheimer disease research comes of age. The pace accelerates." JAMA (1997). DOI
Khachaturian ZS et al.. "Developing a national strategy to prevent dementia: Leon Thal Symposium 2009." Alzheimers Dement (2010). DOI
Hodes RJ et al.. "Eyes on the prize: federal Alzheimer's research effort aims to facilitate interventions." Alzheimers Dement (2008). DOI
Petanceska S et al.. "Commentary on "a roadmap for the prevention of dementia II. Leon Thal Symposium 2008." Alzheimer's disease translational research programs at the National Institute on Aging." Alzheimers Dement (2009). DOI
Khachaturian ZS et al.. "A roadmap for the prevention of dementia: the inaugural Leon Thal Symposium." Alzheimers Dement (2008). DOI
Wang L et al.. "Dynamic proportional loss of functional connectivity revealed change of left superior frontal gyrus in subjective cognitive decline: an explanatory study based on Chinese and Western cohorts." GeroScience (2025). DOI: 10.1007/s11357-025-01528-6 PubMed: 39888585
Hodes RJ, Buckholtz N. "Accelerating Medicines Partnership: Alzheimer's Disease (AMP-AD) Knowledge Portal Aids Alzheimer's Drug Discovery through Open Data Sharing." Expert opinion on therapeutic targets (2016). DOI: 10.1517/14728222.2016.1135132 PubMed: 26853544
Jones-Davis DM, Buckholtz N. "The impact of the Alzheimer's Disease Neuroimaging Initiative 2: What role do public-private partnerships have in pushing the boundaries of clinical and basic science research on Alzheimer's disease?." Alzheimers Dement (2015). DOI: 10.1016/j.jalz.2015.05.006 PubMed: 26194319
Morrison-Bogorad M, Phelps C, Buckholtz N. "Alzheimer disease research comes of age. The pace accelerates." JAMA (1997). DOI: 10.1001/jama.277.10.837 PubMed: 9052716
Khachaturian ZS et al.. "Developing a national strategy to prevent dementia: Leon Thal Symposium 2009." Alzheimers Dement (2010). DOI: 10.1016/j.jalz.2010.01.008 PubMed: 20298968
Hodes RJ et al.. "Eyes on the prize: federal Alzheimer's research effort aims to facilitate interventions." Alzheimers Dement (2008). DOI: 10.1016/j.jalz.2007.11.002 PubMed: 18631998
Petanceska S et al.. "Commentary on "a roadmap for the prevention of dementia II. Leon Thal Symposium 2008." Alzheimer's disease translational research programs at the National Institute on Aging." Alzheimers Dement (2009). DOI: 10.1016/j.jalz.2009.01.014 PubMed: 19328442
Khachaturian ZS et al.. "A roadmap for the prevention of dementia: the inaugural Leon Thal Symposium." Alzheimers Dement (2008). DOI: 10.1016/j.jalz.2008.03.005 PubMed: 18631960
Collaborator network pending enrichment.
[Morrison-Bogorad M, Phelps C, Buckholtz N. "Alzheimer's Disease research comes of age. The pace accelerates." JAMA (1997). DOI)
[Wang L et al.. "Dynamic proportional loss of functional connectivity revealed change of left superior frontal gyrus in subjective cognitive decline: an explanatory study based on Chinese and Western cohorts." GeroScience (2025). DOI)
[Jones-Davis DM, Buckholtz N. "The impact of the Alzheimer's Disease Neuroimaging Initiative 2: What role do public-private partnerships have in pushing the boundaries of clinical and basic science research on Alzheimer's Disease?." Alzheimers Dement (2015). DOI)
[Hodes RJ, Buckholtz N. "Accelerating Medicines Partnership: Alzheimer's Disease (AMP-AD) Knowledge Portal Aids Alzheimer's Drug Discovery through Open Data Sharing." Expert opinion on therapeutic targets (2016). DOI)
[Khachaturian ZS et al.. "Developing a national strategy to prevent dementia: Leon Thal Symposium 2009." Alzheimers Dement (2010). DOI)
[Petanceska S et al.. "Commentary on "a roadmap for the prevention of dementia II. Leon Thal Symposium 2008." Alzheimer's Disease translational research programs at the National Institute on Aging." Alzheimers Dement (2009). DOI)
[Hodes RJ et al.. "Eyes on the prize: federal Alzheimer's research effort aims to facilitate interventions." Alzheimers Dement (2008). DOI)
[Khachaturian ZS et al.. "A roadmap for the prevention of dementia: the inaugural Leon Thal Symposium." Alzheimers Dement (2008). DOI)
[Morrison-Bogorad M, Phelps C, Buckholtz N. "Alzheimer's Disease research comes of age. The pace accelerates." JAMA (1997). [DOI: 10.1001/jama.277.10.837]https://doi.org/10.1001/jama.277.10.837) PubMed: 9052716
[Wang L et al.. "Dynamic proportional loss of functional connectivity revealed change of left superior frontal gyrus in subjective cognitive decline: an explanatory study based on Chinese and Western cohorts." GeroScience (2025). [DOI: 10.1007/s11357-025-01528-6]https://doi.org/10.1007/s11357-025-01528-6) PubMed: 39888585
[Jones-Davis DM, Buckholtz N. "The impact of the Alzheimer's Disease Neuroimaging Initiative 2: What role do public-private partnerships have in pushing the boundaries of clinical and basic science research on Alzheimer's Disease?." Alzheimers Dement (2015). [DOI: 10.1016/j.jalz.2015.05.006]https://doi.org/10.1016/j.jalz.2015.05.006) PubMed: 26194319
[Hodes RJ, Buckholtz N. "Accelerating Medicines Partnership: Alzheimer's Disease (AMP-AD) Knowledge Portal Aids Alzheimer's Drug Discovery through Open Data Sharing." Expert opinion on therapeutic targets (2016). [DOI: 10.1517/14728222.2016.1135132]https://doi.org/10.1517/14728222.2016.1135132) PubMed: 26853544
[Khachaturian ZS et al.. "Developing a national strategy to prevent dementia: Leon Thal Symposium 2009." Alzheimers Dement (2010). [DOI: 10.1016/j.jalz.2010.01.008]https://doi.org/10.1016/j.jalz.2010.01.008) PubMed: 20298968
[Petanceska S et al.. "Commentary on "a roadmap for the prevention of dementia II. Leon Thal Symposium 2008." Alzheimer's Disease translational research programs at the National Institute on Aging." Alzheimers Dement (2009). [DOI: 10.1016/j.jalz.2009.01.014]https://doi.org/10.1016/j.jalz.2009.01.014) PubMed: 19328442
[Hodes RJ et al.. "Eyes on the prize: federal Alzheimer's research effort aims to facilitate interventions." Alzheimers Dement (2008). [DOI: 10.1016/j.jalz.2007.11.002]https://doi.org/10.1016/j.jalz.2007.11.002) PubMed: 18631998
[Khachaturian ZS et al.. "A roadmap for the prevention of dementia: the inaugural Leon Thal Symposium." Alzheimers Dement (2008). [DOI: 10.1016/j.jalz.2008.03.005]https://doi.org/10.1016/j.jalz.2008.03.005) PubMed: 18631960
[Morrison-Bogorad M, Phelps C, Buckholtz N. "Alzheimer's Disease research comes of age. The pace accelerates." JAMA (1997). DOI)
[Wang L et al.. "Dynamic proportional loss of functional connectivity revealed change of left superior frontal gyrus in subjective cognitive decline: an explanatory study based on Chinese and Western cohorts." GeroScience (2025). DOI)
[Jones-Davis DM, Buckholtz N. "The impact of the Alzheimer's Disease Neuroimaging Initiative 2: What role do public-private partnerships have in pushing the boundaries of clinical and basic science research on Alzheimer's Disease?." Alzheimers Dement (2015). DOI)
[Hodes RJ, Buckholtz N. "Accelerating Medicines Partnership: Alzheimer's Disease (AMP-AD) Knowledge Portal Aids Alzheimer's Drug Discovery through Open Data Sharing." Expert opinion on therapeutic targets (2016). DOI)
[Khachaturian ZS et al.. "Developing a national strategy to prevent dementia: Leon Thal Symposium 2009." Alzheimers Dement (2010). DOI)
[Petanceska S et al.. "Commentary on "a roadmap for the prevention of dementia II. Leon Thal Symposium 2008." Alzheimer's Disease translational research programs at the National Institute on Aging." Alzheimers Dement (2009). DOI)
[Hodes RJ et al.. "Eyes on the prize: federal Alzheimer's research effort aims to facilitate interventions." Alzheimers Dement (2008). DOI)
[Khachaturian ZS et al.. "A roadmap for the prevention of dementia: the inaugural Leon Thal Symposium." Alzheimers Dement (2008). DOI)
[Morrison-Bogorad M, Phelps C, Buckholtz N. "Alzheimer's Disease research comes of age. The pace accelerates." JAMA (1997). [DOI: 10.1001/jama.277.10.837]https://doi.org/10.1001/jama.277.10.837) PubMed: 9052716
[Wang L et al.. "Dynamic proportional loss of functional connectivity revealed change of left superior frontal gyrus in subjective cognitive decline: an explanatory study based on Chinese and Western cohorts." GeroScience (2025). [DOI: 10.1007/s11357-025-01528-6]https://doi.org/10.1007/s11357-025-01528-6) PubMed: 39888585
[Jones-Davis DM, Buckholtz N. "The impact of the Alzheimer's Disease Neuroimaging Initiative 2: What role do public-private partnerships have in pushing the boundaries of clinical and basic science research on Alzheimer's Disease?." Alzheimers Dement (2015). [DOI: 10.1016/j.jalz.2015.05.006]https://doi.org/10.1016/j.jalz.2015.05.006) PubMed: 26194319
[Hodes RJ, Buckholtz N. "Accelerating Medicines Partnership: Alzheimer's Disease (AMP-AD) Knowledge Portal Aids Alzheimer's Drug Discovery through Open Data Sharing." Expert opinion on therapeutic targets (2016). [DOI: 10.1517/14728222.2016.1135132]https://doi.org/10.1517/14728222.2016.1135132) PubMed: 26853544
[Khachaturian ZS et al.. "Developing a national strategy to prevent dementia: Leon Thal Symposium 2009." Alzheimers Dement (2010). [DOI: 10.1016/j.jalz.2010.01.008]https://doi.org/10.1016/j.jalz.2010.01.008) PubMed: 20298968
[Petanceska S et al.. "Commentary on "a roadmap for the prevention of dementia II. Leon Thal Symposium 2008." Alzheimer's Disease translational research programs at the National Institute on Aging." Alzheimers Dement (2009). [DOI: 10.1016/j.jalz.2009.01.014]https://doi.org/10.1016/j.jalz.2009.01.014) PubMed: 19328442
[Hodes RJ et al.. "Eyes on the prize: federal Alzheimer's research effort aims to facilitate interventions." Alzheimers Dement (2008). [DOI: 10.1016/j.jalz.2007.11.002]https://doi.org/10.1016/j.jalz.2007.11.002) PubMed: 18631998
[Khachaturian ZS et al.. "A roadmap for the prevention of dementia: the inaugural Leon Thal Symposium." Alzheimers Dement (2008). [DOI: 10.1016/j.jalz.2008.03.005]https://doi.org/10.1016/j.jalz.2008.03.005) PubMed: 18631960
[Morrison-Bogorad M, Phelps C, Buckholtz N. "Alzheimer's Disease research comes of age. The pace accelerates." JAMA (1997). DOI)
[Wang L et al.. "Dynamic proportional loss of functional connectivity revealed change of left superior frontal gyrus in subjective cognitive decline: an explanatory study based on Chinese and Western cohorts." GeroScience (2025). DOI)
[Jones-Davis DM, Buckholtz N. "The impact of the Alzheimer's Disease Neuroimaging Initiative 2: What role do public-private partnerships have in pushing the boundaries of clinical and basic science research on Alzheimer's Disease?." Alzheimers Dement (2015). DOI)
[Hodes RJ, Buckholtz N. "Accelerating Medicines Partnership: Alzheimer's Disease (AMP-AD) Knowledge Portal Aids Alzheimer's Drug Discovery through Open Data Sharing." Expert opinion on therapeutic targets (2016). DOI)
[Khachaturian ZS et al.. "Developing a national strategy to prevent dementia: Leon Thal Symposium 2009." Alzheimers Dement (2010). DOI)
[Petanceska S et al.. "Commentary on "a roadmap for the prevention of dementia II. Leon Thal Symposium 2008." Alzheimer's Disease translational research programs at the National Institute on Aging." Alzheimers Dement (2009). DOI)
[Hodes RJ et al.. "Eyes on the prize: federal Alzheimer's research effort aims to facilitate interventions." Alzheimers Dement (2008). DOI)
[Khachaturian ZS et al.. "A roadmap for the prevention of dementia: the inaugural Leon Thal Symposium." Alzheimers Dement (2008). DOI)
[Morrison-Bogorad M, Phelps C, Buckholtz N. "Alzheimer's Disease research comes of age. The pace accelerates." JAMA (1997). [DOI: 10.1001/jama.277.10.837]https://doi.org/10.1001/jama.277.10.837) PubMed: 9052716
[Wang L et al.. "Dynamic proportional loss of functional connectivity revealed change of left superior frontal gyrus in subjective cognitive decline: an explanatory study based on Chinese and Western cohorts." GeroScience (2025). [DOI: 10.1007/s11357-025-01528-6]https://doi.org/10.1007/s11357-025-01528-6) PubMed: 39888585
[Jones-Davis DM, Buckholtz N. "The impact of the Alzheimer's Disease Neuroimaging Initiative 2: What role do public-private partnerships have in pushing the boundaries of clinical and basic science research on Alzheimer's Disease?." Alzheimers Dement (2015). [DOI: 10.1016/j.jalz.2015.05.006]https://doi.org/10.1016/j.jalz.2015.05.006) PubMed: 26194319
[Hodes RJ, Buckholtz N. "Accelerating Medicines Partnership: Alzheimer's Disease (AMP-AD) Knowledge Portal Aids Alzheimer's Drug Discovery through Open Data Sharing." Expert opinion on therapeutic targets (2016). [DOI: 10.1517/14728222.2016.1135132]https://doi.org/10.1517/14728222.2016.1135132) PubMed: 26853544
[Khachaturian ZS et al.. "Developing a national strategy to prevent dementia: Leon Thal Symposium 2009." Alzheimers Dement (2010). [DOI: 10.1016/j.jalz.2010.01.008]https://doi.org/10.1016/j.jalz.2010.01.008) PubMed: 20298968
[Petanceska S et al.. "Commentary on "a roadmap for the prevention of dementia II. Leon Thal Symposium 2008." Alzheimer's Disease translational research programs at the National Institute on Aging." Alzheimers Dement (2009). [DOI: 10.1016/j.jalz.2009.01.014]https://doi.org/10.1016/j.jalz.2009.01.014) PubMed: 19328442
[Hodes RJ et al.. "Eyes on the prize: federal Alzheimer's research effort aims to facilitate interventions." Alzheimers Dement (2008). [DOI: 10.1016/j.jalz.2007.11.002]https://doi.org/10.1016/j.jalz.2007.11.002) PubMed: 18631998
[Khachaturian ZS et al.. "A roadmap for the prevention of dementia: the inaugural Leon Thal Symposium." Alzheimers Dement (2008). [DOI: 10.1016/j.jalz.2008.03.005]https://doi.org/10.1016/j.jalz.2008.03.005) PubMed: 18631960
[Morrison-Bogorad M, Phelps C, Buckholtz N. "Alzheimer's Disease research comes of age. The pace accelerates." JAMA (1997). DOI)
[Wang L et al.. "Dynamic proportional loss of functional connectivity revealed change of left superior frontal gyrus in subjective cognitive decline: an explanatory study based on Chinese and Western cohorts." GeroScience (2025). DOI)
[Jones-Davis DM, Buckholtz N. "The impact of the Alzheimer's Disease Neuroimaging Initiative 2: What role do public-private partnerships have in pushing the boundaries of clinical and basic science research on Alzheimer's Disease?." Alzheimers Dement (2015). DOI)
[Hodes RJ, Buckholtz N. "Accelerating Medicines Partnership: Alzheimer's Disease (AMP-AD) Knowledge Portal Aids Alzheimer's Drug Discovery through Open Data Sharing." Expert opinion on therapeutic targets (2016). DOI)
[Khachaturian ZS et al.. "Developing a national strategy to prevent dementia: Leon Thal Symposium 2009." Alzheimers Dement (2010). DOI)
[Petanceska S et al.. "Commentary on "a roadmap for the prevention of dementia II. Leon Thal Symposium 2008." Alzheimer's Disease translational research programs at the National Institute on Aging." Alzheimers Dement (2009). DOI)
[Hodes RJ et al.. "Eyes on the prize: federal Alzheimer's research effort aims to facilitate interventions." Alzheimers Dement (2008). DOI)
[Khachaturian ZS et al.. "A roadmap for the prevention of dementia: the inaugural Leon Thal Symposium." Alzheimers Dement (2008). DOI)
[Morrison-Bogorad M, Phelps C, Buckholtz N. "Alzheimer's Disease research comes of age. The pace accelerates." JAMA (1997). [DOI: 10.1001/jama.277.10.837]https://doi.org/10.1001/jama.277.10.837) PubMed: 9052716
[Wang L et al.. "Dynamic proportional loss of functional connectivity revealed change of left superior frontal gyrus in subjective cognitive decline: an explanatory study based on Chinese and Western cohorts." GeroScience (2025). [DOI: 10.1007/s11357-025-01528-6]https://doi.org/10.1007/s11357-025-01528-6) PubMed: 39888585
[Jones-Davis DM, Buckholtz N. "The impact of the Alzheimer's Disease Neuroimaging Initiative 2: What role do public-private partnerships have in pushing the boundaries of clinical and basic science research on Alzheimer's Disease?." Alzheimers Dement (2015). [DOI: 10.1016/j.jalz.2015.05.006]https://doi.org/10.1016/j.jalz.2015.05.006) PubMed: 26194319
[Hodes RJ, Buckholtz N. "Accelerating Medicines Partnership: Alzheimer's Disease (AMP-AD) Knowledge Portal Aids Alzheimer's Drug Discovery through Open Data Sharing." Expert opinion on therapeutic targets (2016). [DOI: 10.1517/14728222.2016.1135132]https://doi.org/10.1517/14728222.2016.1135132) PubMed: 26853544
[Khachaturian ZS et al.. "Developing a national strategy to prevent dementia: Leon Thal Symposium 2009." Alzheimers Dement (2010). [DOI: 10.1016/j.jalz.2010.01.008]https://doi.org/10.1016/j.jalz.2010.01.008) PubMed: 20298968
[Petanceska S et al.. "Commentary on "a roadmap for the prevention of dementia II. Leon Thal Symposium 2008." Alzheimer's Disease translational research programs at the National Institute on Aging." Alzheimers Dement (2009). [DOI: 10.1016/j.jalz.2009.01.014]https://doi.org/10.1016/j.jalz.2009.01.014) PubMed: 19328442
[Hodes RJ et al.. "Eyes on the prize: federal Alzheimer's research effort aims to facilitate interventions." Alzheimers Dement (2008). [DOI: 10.1016/j.jalz.2007.11.002]https://doi.org/10.1016/j.jalz.2007.11.002) PubMed: 18631998
[Khachaturian ZS et al.. "A roadmap for the prevention of dementia: the inaugural Leon Thal Symposium." Alzheimers Dement (2008). [DOI: 10.1016/j.jalz.2008.03.005]https://doi.org/10.1016/j.jalz.2008.03.005) PubMed: 18631960
Recent publications by [Neil W. Buckholtz--TEMP--/researchers)--FIX-- focus on translational neuroscience, drug development, and federal research programs for [Alzheimer's disease--TEMP--/diseases)--FIX--.
The study of Neil W. Buckholtz has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.