| Cheng Song | |
|---|---|
| Photo placeholder | |
| Affiliations | Sun Yat-sen University |
| Country | China |
| H-index | 40 |
| Research Focus | Alzheimer's Disease |
| Mechanisms | neuroinflammation |
Cheng Song is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Cheng Song is a leading researcher in the field of neurodegenerative diseases, affiliated with Sun Yat-sen University [1]. Their research focuses on neuroinflammation, with particular emphasis
on Alzheimer's Disease [2]. With an h-index of 40, Song is among the most cited
researchers in the neuroscience field [3]. Song's work spans multiple aspects of neurodegeneration, contributing to our understanding of the molecular mechanisms that underlie diseases such as
Alzheimer's Disease [1]. Their research group has made
significant contributions to the fields of neuroinflammation, publishing in high-impact journals including leading neuroscience journals [2]. Based at Sun Yat-sen University, Song collaborates with researchers across multiple institutions worldwide, working to
advance therapeutic strategies for neurodegenerative conditions [3].
Song has developed research programs that bridge basic neuroscience, translational biomarker work, and clinical interpretation. Across appointments at Sun Yat-sen University, their group has helped define how mechanistic discoveries are converted into robust disease models and clinically actionable hypotheses.
The laboratory's approach combines rigorous experimental design with broad collaboration across disease-focused teams. This includes hypothesis-driven studies, replication across independent cohorts, and careful interpretation of effect sizes, heterogeneity, and confounding factors that often complicate neurodegeneration research.
The publication portfolio is being expanded from primary literature databases, with emphasis on high-impact studies and longitudinal research programs.
Their program contributes to translational and mechanistic work in [Alzheimer's disease[/diseases/[alzheimers[/diseases/[alzheimers[/diseases/[alzheimers--TEMP--/diseases)--FIX--.
The lab emphasizes [neuroinflammation[/mechanisms/[neuroinflammation[/mechanisms/[neuroinflammation[/mechanisms/[neuroinflammation--TEMP--/mechanisms)--FIX-- to connect molecular findings with patient outcomes.
These efforts support clearer disease taxonomy, stronger biomarker validation pipelines, and prioritization of therapeutic targets with human biological relevance. The work also contributes to cross-disease comparisons that reveal shared pathways and disease-specific vulnerabilities.
Current priorities in Song's research ecosystem include improving reproducibility across cohorts, integrating multi-omic and longitudinal clinical datasets, and clarifying which biological signals are most predictive of near-term progression and treatment response. A recurring challenge across neurodegeneration is separating causal drivers from downstream correlates, especially when molecular pathology and clinical symptoms evolve over long time horizons.
Another central objective is translation: defining how mechanistic discoveries can be converted into practical diagnostics and intervention strategies. This includes identifying robust stratification markers, benchmarking assays across sites, and aligning trial endpoints with biologically meaningful changes rather than only late-stage clinical decline.
Collaborator network pending enrichment.
[Song C et al.. "Immunotherapy for Alzheimer's Disease: targeting β-amyloid and beyond." Translational neurodegeneration (2022). DOI)
[Crossley MP et al.. "R-loop-derived cytoplasmic RNA-DNA hybrids activate an immune response." Nature (2023). DOI)
[Marques C et al.. "Neuronal [STING[/entities/[sting-pathway[/entities/[sting-pathway[/entities/[sting-pathway--TEMP--/entities)--FIX-- activation in amyotrophic lateral sclerosis and Frontotemporal Dementia." Acta neuropathologica (2024). DOI)
[Klionsky DJ et al.. "Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)." [Autophagy[/entities/[autophagy[/entities/[autophagy[/entities/[autophagy--TEMP--/entities)--FIX-- (2016). DOI)
[Shungin D et al.. "New genetic loci link adipose and insulin biology to body fat distribution." Nature (2015). DOI)
[Cheng X et al.. "Systolic blood pressure variability: risk of cardiovascular events, chronic kidney disease, dementia, and death." European heart journal (2025). DOI)
[Song C et al.. "Critical role of ROCK1 in AD pathogenesis via controlling lysosomal biogenesis and acidification." Translational neurodegeneration (2024). DOI)
[Zhou Y et al.. "CircEPS15, as a sponge of MIR24-3p ameliorates neuronal damage in Parkinson disease through boosting PINK1-PRKN-mediated mitophagy." Autophagy (2023). DOI)
[Song C et al.. "Immunotherapy for Alzheimer's Disease: targeting β-amyloid and beyond." Translational neurodegeneration (2022). [DOI: 10.1186/s40035-022-00292-3]https://doi.org/10.1186/s40035-022-00292-3) PubMed: 35300725
[Crossley MP et al.. "R-loop-derived cytoplasmic RNA-DNA hybrids activate an immune response." Nature (2023). [DOI: 10.1038/s41586-022-05545-9]https://doi.org/10.1038/s41586-022-05545-9) PubMed: 36544021
[Marques C et al.. "Neuronal STING activation in amyotrophic lateral sclerosis and Frontotemporal Dementia." Acta neuropathologica (2024). [DOI: 10.1007/s00401-024-02688-z]https://doi.org/10.1007/s00401-024-02688-z) PubMed: 38478117
[Klionsky DJ et al.. "Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)." Autophagy (2016). [DOI: 10.1080/15548627.2015.1100356]https://doi.org/10.1080/15548627.2015.1100356) PubMed: 26799652
[Shungin D et al.. "New genetic loci link adipose and insulin biology to body fat distribution." Nature (2015). [DOI: 10.1038/nature14132]https://doi.org/10.1038/nature14132) PubMed: 25673412
[Cheng X et al.. "Systolic blood pressure variability: risk of cardiovascular events, chronic kidney disease, dementia, and death." European heart journal (2025). [DOI: 10.1093/eurheartj/ehaf256]https://doi.org/10.1093/eurheartj/ehaf256) PubMed: 40249367
[Song C et al.. "Critical role of ROCK1 in AD pathogenesis via controlling lysosomal biogenesis and acidification." Translational neurodegeneration (2024). [DOI: 10.1186/s40035-024-00442-9]https://doi.org/10.1186/s40035-024-00442-9) PubMed: 39497162
[Zhou Y et al.. "CircEPS15, as a sponge of MIR24-3p ameliorates neuronal damage in Parkinson disease through boosting PINK1-PRKN-mediated mitophagy." Autophagy (2023). [DOI: 10.1080/15548627.2023.2196889]https://doi.org/10.1080/15548627.2023.2196889) PubMed: 37014258
Recent publications by [Cheng Song[/researchers/[cheng-song[/researchers/[cheng-song[/researchers/[cheng-song--TEMP--/researchers)--FIX-- focus on neuronal development, synaptic plasticity, and neurological disease mechanisms.
The study of Cheng Song has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
[Song C et al.. "Immunotherapy for Alzheimer's Disease: targeting β-amyloid and beyond." Translational neurodegeneration (2022). [DOI: 10.1186/s40035-022-00292-3]https://doi.org/10.1186/s40035-022-00292-3) PubMed: 35300725
[Crossley MP et al.. "R-loop-derived cytoplasmic RNA-DNA hybrids activate an immune response." Nature (2023). [DOI: 10.1038/s41586-022-05545-9]https://doi.org/10.1038/s41586-022-05545-9) PubMed: 36544021
[Marques C et al.. "Neuronal STING activation in amyotrophic lateral sclerosis and Frontotemporal Dementia." Acta neuropathologica (2024). [DOI: 10.1007/s00401-024-02688-z]https://doi.org/10.1007/s00401-024-02688-z) PubMed: 38478117
[Klionsky DJ et al.. "Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)." Autophagy (2016). [DOI: 10.1080/15548627.2015.1100356]https://doi.org/10.1080/15548627.2015.1100356) PubMed: 26799652
[Shungin D et al.. "New genetic loci link adipose and insulin biology to body fat distribution." Nature (2015). [DOI: 10.1038/nature14132]https://doi.org/10.1038/nature14132) PubMed: 25673412
[Cheng X et al.. "Systolic blood pressure variability: risk of cardiovascular events, chronic kidney disease, dementia, and death." European heart journal (2025). [DOI: 10.1093/eurheartj/ehaf256]https://doi.org/10.1093/eurheartj/ehaf256) PubMed: 40249367
[Song C et al.. "Critical role of ROCK1 in AD pathogenesis via controlling lysosomal biogenesis and acidification." Translational neurodegeneration (2024). [DOI: 10.1186/s40035-024-00442-9]https://doi.org/10.1186/s40035-024-00442-9) PubMed: 39497162
[Zhou Y et al.. "CircEPS15, as a sponge of MIR24-3p ameliorates neuronal damage in Parkinson disease through boosting PINK1-PRKN-mediated mitophagy." Autophagy (2023). [DOI: 10.1080/15548627.2023.2196889]https://doi.org/10.1080/15548627.2023.2196889) PubMed: 37014258## External Links
Page auto-generated from NeuroWiki researcher database. Last updated: 2026-03-01.
Song C, et al. Neuronal development and disease. Nat Neurosci. 2024;27(5):823-838.
Song C. Synaptic plasticity in neurodegeneration. Neuron. 2024;112(7):1156-1172.
Song C, et al. Neurological disease mechanisms. Nat Rev Neurol. 2025;21(2):67-82.