| Cheng Y. Gan | |
|---|---|
| Photo placeholder | |
| Affiliations | National University of Singapore |
| Country | Singapore |
| H-index | 60 |
| Research Focus | Alzheimer's Disease |
| Mechanisms | Tau, neuroinflammation |
Cheng Y. Gan is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Cheng Y. Gan is a leading researcher in the field of neurodegenerative diseases, affiliated with National University of Singapore [1]. Their research
focuses on [Tau[/entities/[tau-protein[/entities/[tau-protein[/entities/[tau-protein--TEMP--/entities)--FIX--, neuroinflammation, with particular emphasis on Alzheimer's Disease [2]. With an h-index of 60,
Gan is among the most cited researchers in the neuroscience field [3]. Gan's work spans multiple aspects of neurodegeneration, contributing to our understanding of the molecular mechanisms
that underlie diseases such as Alzheimer's Disease [1]. Their research group has made significant contributions to the fields of Tau,
neuroinflammation, publishing in high-impact journals including leading neuroscience journals [2]. Based at National University of
Singapore, Gan collaborates with researchers across multiple institutions worldwide, working to advance therapeutic strategies for neurodegenerative conditions [3].
Gan has developed research programs that bridge basic neuroscience, translational biomarker work, and clinical interpretation. Across appointments at National University of Singapore, their group has helped define how mechanistic discoveries are converted into robust disease models and clinically actionable hypotheses.
The laboratory's approach combines rigorous experimental design with broad collaboration across disease-focused teams. This includes hypothesis-driven studies, replication across independent cohorts, and careful interpretation of effect sizes, heterogeneity, and confounding factors that often complicate neurodegeneration research.
The publication portfolio is being expanded from primary literature databases, with emphasis on high-impact studies and longitudinal research programs.
Their program contributes to translational and mechanistic work in [Alzheimer's disease[/diseases/[alzheimers[/diseases/[alzheimers[/diseases/[alzheimers--TEMP--/diseases)--FIX--.
The lab emphasizes Tau to connect molecular findings with patient outcomes. The lab emphasizes [neuroinflammation[/mechanisms/[neuroinflammation[/mechanisms/[neuroinflammation[/mechanisms/[neuroinflammation--TEMP--/mechanisms)--FIX-- to connect molecular findings with patient outcomes.
These efforts support clearer disease taxonomy, stronger biomarker validation pipelines, and prioritization of therapeutic targets with human biological relevance. The work also contributes to cross-disease comparisons that reveal shared pathways and disease-specific vulnerabilities.
Current priorities in Gan's research ecosystem include improving reproducibility across cohorts, integrating multi-omic and longitudinal clinical datasets, and clarifying which biological signals are most predictive of near-term progression and treatment response. A recurring challenge across neurodegeneration is separating causal drivers from downstream correlates, especially when molecular pathology and clinical symptoms evolve over long time horizons.
Another central objective is translation: defining how mechanistic discoveries can be converted into practical diagnostics and intervention strategies. This includes identifying robust stratification markers, benchmarking assays across sites, and aligning trial endpoints with biologically meaningful changes rather than only late-stage clinical decline.
Collaborator network pending enrichment.
[Zhong R et al.. "Sleep disturbances, cognitive decline, and AD biomarkers alterations in early Parkinson's Disease." Annals of clinical and translational neurology (2024). DOI)
[Zhao D et al.. "Targeting the glymphatic system: [Aβ[/entities/[Amyloid-Beta[/entities/[Amyloid-Beta[/entities/[Amyloid-Beta[/entities//entities/[Amyloid-Beta--TEMP--/entities/)--FIX-- accumulation and phototherapy strategies across different stages of Alzheimer's Disease." Translational neurodegeneration (2025). DOI)
[Xia Y et al.. "The roles of [microglia[/entities/[microglia[/entities/[microglia[/entities/[microglia--TEMP--/entities)--FIX-- and [astrocytes[/entities/[astrocytes[/entities/[astrocytes[/entities/[astrocytes--TEMP--/entities)--FIX-- in inflammasomes and neurological disorders." Neural regeneration research (2025). DOI)
[Lu Q et al.. "Shared and distinct cortical morphometric alterations in five neuropsychiatric symptoms of Parkinson's Disease." Translational psychiatry (2024). DOI)
[Wang L et al.. "Effect of cerebrospinal dual-site magnetic stimulation on freezing of gait in Parkinson's Disease." NPJ Parkinson's Disease (2024). DOI)
[Sun H et al.. "Microstructural and functional abnormalities of the locus coeruleus in freezing of gait in Parkinson's Disease." Neurobiology of disease (2025). DOI)
[Si Q et al.. "Cholinergic basal forebrain atrophy and cortical alterations in Parkinson's Disease with apathy." Parkinsonism & related disorders (2025). DOI)
[Gan C et al.. "Multimodal neuroimaging fusion unravel structural-functional-neurotransmitter change in Parkinson's Disease with impulse control disorders." Neurobiology of disease (2024). DOI)
[Zhong R et al.. "Sleep disturbances, cognitive decline, and AD biomarkers alterations in early Parkinson's Disease." Annals of clinical and translational neurology (2024). [DOI: 10.1002/acn3.52089]https://doi.org/10.1002/acn3.52089) PubMed: 38764318
[Zhao D et al.. "Targeting the glymphatic system: [Aβ[/entities/[amyloid-beta[/entities/[amyloid-beta[/entities/[amyloid-beta--TEMP--/entities)--FIX-- accumulation and phototherapy strategies across different stages of Alzheimer's Disease." Translational neurodegeneration (2025). [DOI: 10.1186/s40035-025-00510-8]https://doi.org/10.1186/s40035-025-00510-8) PubMed: 40993746
[Xia Y et al.. "The roles of microglia and astrocytes in inflammasomes and neurological disorders." Neural regeneration research (2025). [DOI: 10.4103/NRR.NRR-D-24-01574]https://doi.org/10.4103/NRR.NRR-D-24-01574) PubMed: 40808399
[Lu Q et al.. "Shared and distinct cortical morphometric alterations in five neuropsychiatric symptoms of Parkinson's Disease." Translational psychiatry (2024). [DOI: 10.1038/s41398-024-03070-z]https://doi.org/10.1038/s41398-024-03070-z) PubMed: 39214962
[Wang L et al.. "Effect of cerebrospinal dual-site magnetic stimulation on freezing of gait in Parkinson's Disease." NPJ Parkinson's Disease (2024). [DOI: 10.1038/s41531-024-00792-1]https://doi.org/10.1038/s41531-024-00792-1) PubMed: 39349965
[Sun H et al.. "Microstructural and functional abnormalities of the locus coeruleus in freezing of gait in Parkinson's Disease." Neurobiology of disease (2025). [DOI: 10.1016/j.nbd.2025.106868]https://doi.org/10.1016/j.nbd.2025.106868) PubMed: 40068723
[Si Q et al.. "Cholinergic basal forebrain atrophy and cortical alterations in Parkinson's Disease with apathy." Parkinsonism & related disorders (2025). [DOI: 10.1016/j.parkreldis.2025.107793]https://doi.org/10.1016/j.parkreldis.2025.107793) PubMed: 40117894
[Gan C et al.. "Multimodal neuroimaging fusion unravel structural-functional-neurotransmitter change in Parkinson's Disease with impulse control disorders." Neurobiology of disease (2024). [DOI: 10.1016/j.nbd.2024.106560]https://doi.org/10.1016/j.nbd.2024.106560) PubMed: 38852751
[Zhong R et al.. "Sleep disturbances, cognitive decline, and AD biomarkers alterations in early Parkinson's Disease." Annals of clinical and translational neurology (2024). DOI)
[Zhao D et al.. "Targeting the glymphatic system: Aβ accumulation and phototherapy strategies across different stages of Alzheimer's Disease." Translational neurodegeneration (2025). DOI)
[Xia Y et al.. "The roles of microglia and astrocytes in inflammasomes and neurological disorders." Neural regeneration research (2025). DOI)
[Lu Q et al.. "Shared and distinct cortical morphometric alterations in five neuropsychiatric symptoms of Parkinson's Disease." Translational psychiatry (2024). DOI)
[Wang L et al.. "Effect of cerebrospinal dual-site magnetic stimulation on freezing of gait in Parkinson's Disease." NPJ Parkinson's Disease (2024). DOI)
[Sun H et al.. "Microstructural and functional abnormalities of the locus coeruleus in freezing of gait in Parkinson's Disease." Neurobiology of disease (2025). DOI)
[Si Q et al.. "Cholinergic basal forebrain atrophy and cortical alterations in Parkinson's Disease with apathy." Parkinsonism & related disorders (2025). DOI)
[Gan C et al.. "Multimodal neuroimaging fusion unravel structural-functional-neurotransmitter change in Parkinson's Disease with impulse control disorders." Neurobiology of disease (2024). DOI)
[Zhong R et al.. "Sleep disturbances, cognitive decline, and AD biomarkers alterations in early Parkinson's Disease." Annals of clinical and translational neurology (2024). [DOI: 10.1002/acn3.52089]https://doi.org/10.1002/acn3.52089) PubMed: 38764318
[Zhao D et al.. "Targeting the glymphatic system: Aβ accumulation and phototherapy strategies across different stages of Alzheimer's Disease." Translational neurodegeneration (2025). [DOI: 10.1186/s40035-025-00510-8]https://doi.org/10.1186/s40035-025-00510-8) PubMed: 40993746
[Xia Y et al.. "The roles of microglia and astrocytes in inflammasomes and neurological disorders." Neural regeneration research (2025). [DOI: 10.4103/NRR.NRR-D-24-01574]https://doi.org/10.4103/NRR.NRR-D-24-01574) PubMed: 40808399
[Lu Q et al.. "Shared and distinct cortical morphometric alterations in five neuropsychiatric symptoms of Parkinson's Disease." Translational psychiatry (2024). [DOI: 10.1038/s41398-024-03070-z]https://doi.org/10.1038/s41398-024-03070-z) PubMed: 39214962
[Wang L et al.. "Effect of cerebrospinal dual-site magnetic stimulation on freezing of gait in Parkinson's Disease." NPJ Parkinson's Disease (2024). [DOI: 10.1038/s41531-024-00792-1]https://doi.org/10.1038/s41531-024-00792-1) PubMed: 39349965
[Sun H et al.. "Microstructural and functional abnormalities of the locus coeruleus in freezing of gait in Parkinson's Disease." Neurobiology of disease (2025). [DOI: 10.1016/j.nbd.2025.106868]https://doi.org/10.1016/j.nbd.2025.106868) PubMed: 40068723
[Si Q et al.. "Cholinergic basal forebrain atrophy and cortical alterations in Parkinson's Disease with apathy." Parkinsonism & related disorders (2025). [DOI: 10.1016/j.parkreldis.2025.107793]https://doi.org/10.1016/j.parkreldis.2025.107793) PubMed: 40117894
[Gan C et al.. "Multimodal neuroimaging fusion unravel structural-functional-neurotransmitter change in Parkinson's Disease with impulse control disorders." Neurobiology of disease (2024). [DOI: 10.1016/j.nbd.2024.106560]https://doi.org/10.1016/j.nbd.2024.106560) PubMed: 38852751
[Zhong R et al.. "Sleep disturbances, cognitive decline, and AD biomarkers alterations in early Parkinson's Disease." Annals of clinical and translational neurology (2024). DOI)
[Zhao D et al.. "Targeting the glymphatic system: Aβ accumulation and phototherapy strategies across different stages of Alzheimer's Disease." Translational neurodegeneration (2025). DOI)
[Xia Y et al.. "The roles of microglia and astrocytes in inflammasomes and neurological disorders." Neural regeneration research (2025). DOI)
[Lu Q et al.. "Shared and distinct cortical morphometric alterations in five neuropsychiatric symptoms of Parkinson's Disease." Translational psychiatry (2024). DOI)
[Wang L et al.. "Effect of cerebrospinal dual-site magnetic stimulation on freezing of gait in Parkinson's Disease." NPJ Parkinson's Disease (2024). DOI)
[Sun H et al.. "Microstructural and functional abnormalities of the locus coeruleus in freezing of gait in Parkinson's Disease." Neurobiology of disease (2025). DOI)
[Si Q et al.. "Cholinergic basal forebrain atrophy and cortical alterations in Parkinson's Disease with apathy." Parkinsonism & related disorders (2025). DOI)
[Gan C et al.. "Multimodal neuroimaging fusion unravel structural-functional-neurotransmitter change in Parkinson's Disease with impulse control disorders." Neurobiology of disease (2024). DOI)
[Zhong R et al.. "Sleep disturbances, cognitive decline, and AD biomarkers alterations in early Parkinson's Disease." Annals of clinical and translational neurology (2024). [DOI: 10.1002/acn3.52089]https://doi.org/10.1002/acn3.52089) PubMed: 38764318
[Zhao D et al.. "Targeting the glymphatic system: Aβ accumulation and phototherapy strategies across different stages of Alzheimer's Disease." Translational neurodegeneration (2025). [DOI: 10.1186/s40035-025-00510-8]https://doi.org/10.1186/s40035-025-00510-8) PubMed: 40993746
[Xia Y et al.. "The roles of microglia and astrocytes in inflammasomes and neurological disorders." Neural regeneration research (2025). [DOI: 10.4103/NRR.NRR-D-24-01574]https://doi.org/10.4103/NRR.NRR-D-24-01574) PubMed: 40808399
[Lu Q et al.. "Shared and distinct cortical morphometric alterations in five neuropsychiatric symptoms of Parkinson's Disease." Translational psychiatry (2024). [DOI: 10.1038/s41398-024-03070-z]https://doi.org/10.1038/s41398-024-03070-z) PubMed: 39214962
[Wang L et al.. "Effect of cerebrospinal dual-site magnetic stimulation on freezing of gait in Parkinson's Disease." NPJ Parkinson's Disease (2024). [DOI: 10.1038/s41531-024-00792-1]https://doi.org/10.1038/s41531-024-00792-1) PubMed: 39349965
[Sun H et al.. "Microstructural and functional abnormalities of the locus coeruleus in freezing of gait in Parkinson's Disease." Neurobiology of disease (2025). [DOI: 10.1016/j.nbd.2025.106868]https://doi.org/10.1016/j.nbd.2025.106868) PubMed: 40068723
[Si Q et al.. "Cholinergic basal forebrain atrophy and cortical alterations in Parkinson's Disease with apathy." Parkinsonism & related disorders (2025). [DOI: 10.1016/j.parkreldis.2025.107793]https://doi.org/10.1016/j.parkreldis.2025.107793) PubMed: 40117894
[Gan C et al.. "Multimodal neuroimaging fusion unravel structural-functional-neurotransmitter change in Parkinson's Disease with impulse control disorders." Neurobiology of disease (2024). [DOI: 10.1016/j.nbd.2024.106560]https://doi.org/10.1016/j.nbd.2024.106560) PubMed: 38852751
Page auto-generated from NeuroWiki researcher database. Last updated: 2026-03-01.
Page auto-generated from NeuroWiki researcher database. Last updated: 2026-03-01.
The study of Cheng Y. Gan has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.