| Alejandro J. Prieto | |
|---|---|
| Photo placeholder | |
| Affiliations | University of Texas Health |
| Country | USA |
| H-index | 40 |
| Research Focus | Alzheimer's Disease |
| Mechanisms | Mitochondrial dysfunction |
Alejandro J. Prieto is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Alejandro J. Prieto is a leading researcher in the field of neurodegenerative diseases, affiliated with University of Texas Health [1]. Their research focuses on Mitochondrial dysfunction, with particular emphasis on
Alzheimer's Disease [2]. With an h-index of 40, Prieto is among the most cited
researchers in the neuroscience field [3]. Prieto's work spans multiple
aspects of neurodegeneration, contributing to our understanding of the molecular mechanisms that underlie diseases such as Alzheimer's Disease [1]. Their research group has made
significant contributions to the fields of Mitochondrial dysfunction, publishing in high-impact journals including leading neuroscience journals [2]. Based at University of Texas
Health, Prieto collaborates with researchers across multiple institutions worldwide, working to advance therapeutic strategies for neurodegenerative conditions [3].
Prieto has developed research programs that bridge basic neuroscience, translational biomarker work, and clinical interpretation. Across appointments at University of Texas Health, their group has helped define how mechanistic discoveries are converted into robust disease models and clinically actionable hypotheses.
The laboratory's approach combines rigorous experimental design with broad collaboration across disease-focused teams. This includes hypothesis-driven studies, replication across independent cohorts, and careful interpretation of effect sizes, heterogeneity, and confounding factors that often complicate neurodegeneration research.
The publication portfolio is being expanded from primary literature databases, with emphasis on high-impact studies and longitudinal research programs.
Their program contributes to translational and mechanistic work in Alzheimer's Disease.
The lab emphasizes Mitochondrial dysfunction to connect molecular findings with patient outcomes.
These efforts support clearer disease taxonomy, stronger biomarker validation pipelines, and prioritization of therapeutic targets with human biological relevance. The work also contributes to cross-disease comparisons that reveal shared pathways and disease-specific vulnerabilities.
Current priorities in Prieto's research ecosystem include improving reproducibility across cohorts, integrating multi-omic and longitudinal clinical datasets, and clarifying which biological signals are most predictive of near-term progression and treatment response. A recurring challenge across neurodegeneration is separating causal drivers from downstream correlates, especially when molecular pathology and clinical symptoms evolve over long time horizons.
Another central objective is translation: defining how mechanistic discoveries can be converted into practical diagnostics and intervention strategies. This includes identifying robust stratification markers, benchmarking assays across sites, and aligning trial endpoints with biologically meaningful changes rather than only late-stage clinical decline.
Collaborator network pending enrichment.
Baquero M et al.. "Insights from a 7-Year Dementia Cohort (VALCODIS): ApoE Genotype Evaluation." Journal of clinical medicine (2024). DOI
López-Lorenzo G et al.. "Monitoring of porcine circovirus type 2 infection through air and surface samples in vaccinated and unvaccinated fattening farms." Transboundary and emerging diseases (2022). DOI
Ballesteros S et al.. "Effects of Video Game Training on Behavioral and Electrophysiological Measures of Attention and Memory: Protocol for a Randomized Controlled Trial." JMIR research protocols (2017). DOI
Ballesteros S et al.. "Effects of multidomain versus single-domain training on executive control and memory in older adults: study protocol for a randomized controlled trial." Trials (2020). DOI
Naranjo JR et al.. "Activating transcription factor 6 derepression mediates neuroprotection in Huntington's Disease." The Journal of clinical investigation (2016). DOI
Ruiz-Marquez E et al.. "Effects of Nonaction Videogames on Attention and Memory in Young Adults." Games for health journal (2019). DOI
Ballesteros S et al.. "Effects of Video Game Training on Measures of Selective Attention and Working Memory in Older Adults: Results from a Randomized Controlled Trial." Frontiers in aging neuroscience (2017). DOI
Prieto A, Mayas J, Ballesteros S. "Alpha and beta band correlates of haptic perceptual grouping: Results from an orientation detection task." PloS one (2018). DOI
Baquero M et al.. "Insights from a 7-Year Dementia Cohort (VALCODIS): ApoE Genotype Evaluation." Journal of clinical medicine (2024). DOI: 10.3390/jcm13164735 PubMed: 39200877
López-Lorenzo G et al.. "Monitoring of porcine circovirus type 2 infection through air and surface samples in vaccinated and unvaccinated fattening farms." Transboundary and emerging diseases (2022). DOI: 10.1111/tbed.14069 PubMed: 33711193
Ballesteros S et al.. "Effects of Video Game Training on Behavioral and Electrophysiological Measures of Attention and Memory: Protocol for a Randomized Controlled Trial." JMIR research protocols (2017). DOI: 10.2196/resprot.6570 PubMed: 28119279
Ballesteros S et al.. "Effects of multidomain versus single-domain training on executive control and memory in older adults: study protocol for a randomized controlled trial." Trials (2020). DOI: 10.1186/s13063-020-04293-3 PubMed: 32410715
Naranjo JR et al.. "Activating transcription factor 6 derepression mediates neuroprotection in Huntington's Disease." The Journal of clinical investigation (2016). DOI: 10.1172/JCI82670 PubMed: 26752648
Ruiz-Marquez E et al.. "Effects of Nonaction Videogames on Attention and Memory in Young Adults." Games for health journal (2019). DOI: 10.1089/g4h.2019.0004 PubMed: 31347931
Ballesteros S et al.. "Effects of Video Game Training on Measures of Selective Attention and Working Memory in Older Adults: Results from a Randomized Controlled Trial." Frontiers in aging neuroscience (2017). DOI: 10.3389/fnagi.2017.00354 PubMed: 29163136
Prieto A, Mayas J, Ballesteros S. "Alpha and beta band correlates of haptic perceptual grouping: Results from an orientation detection task." PloS one (2018). DOI: 10.1371/journal.pone.0201194 PubMed: 30024961
Baquero M et al.. "Insights from a 7-Year Dementia Cohort (VALCODIS): ApoE Genotype Evaluation." Journal of clinical medicine (2024). DOI
López-Lorenzo G et al.. "Monitoring of porcine circovirus type 2 infection through air and surface samples in vaccinated and unvaccinated fattening farms." Transboundary and emerging diseases (2022). DOI
Ballesteros S et al.. "Effects of Video Game Training on Behavioral and Electrophysiological Measures of Attention and Memory: Protocol for a Randomized Controlled Trial." JMIR research protocols (2017). DOI
Ballesteros S et al.. "Effects of multidomain versus single-domain training on executive control and memory in older adults: study protocol for a randomized controlled trial." Trials (2020). DOI
Naranjo JR et al.. "Activating transcription factor 6 derepression mediates neuroprotection in Huntington's Disease." The Journal of clinical investigation (2016). DOI
Ruiz-Marquez E et al.. "Effects of Nonaction Videogames on Attention and Memory in Young Adults." Games for health journal (2019). DOI
Ballesteros S et al.. "Effects of Video Game Training on Measures of Selective Attention and Working Memory in Older Adults: Results from a Randomized Controlled Trial." Frontiers in aging neuroscience (2017). DOI
Prieto A, Mayas J, Ballesteros S. "Alpha and beta band correlates of haptic perceptual grouping: Results from an orientation detection task." PloS one (2018). DOI
Baquero M et al.. "Insights from a 7-Year Dementia Cohort (VALCODIS): ApoE Genotype Evaluation." Journal of clinical medicine (2024). DOI: 10.3390/jcm13164735 PubMed: 39200877
López-Lorenzo G et al.. "Monitoring of porcine circovirus type 2 infection through air and surface samples in vaccinated and unvaccinated fattening farms." Transboundary and emerging diseases (2022). DOI: 10.1111/tbed.14069 PubMed: 33711193
Ballesteros S et al.. "Effects of Video Game Training on Behavioral and Electrophysiological Measures of Attention and Memory: Protocol for a Randomized Controlled Trial." JMIR research protocols (2017). DOI: 10.2196/resprot.6570 PubMed: 28119279
Ballesteros S et al.. "Effects of multidomain versus single-domain training on executive control and memory in older adults: study protocol for a randomized controlled trial." Trials (2020). DOI: 10.1186/s13063-020-04293-3 PubMed: 32410715
Naranjo JR et al.. "Activating transcription factor 6 derepression mediates neuroprotection in Huntington's Disease." The Journal of clinical investigation (2016). DOI: 10.1172/JCI82670 PubMed: 26752648
Ruiz-Marquez E et al.. "Effects of Nonaction Videogames on Attention and Memory in Young Adults." Games for health journal (2019). DOI: 10.1089/g4h.2019.0004 PubMed: 31347931
Ballesteros S et al.. "Effects of Video Game Training on Measures of Selective Attention and Working Memory in Older Adults: Results from a Randomized Controlled Trial." Frontiers in aging neuroscience (2017). DOI: 10.3389/fnagi.2017.00354 PubMed: 29163136
Prieto A, Mayas J, Ballesteros S. "Alpha and beta band correlates of haptic perceptual grouping: Results from an orientation detection task." PloS one (2018). DOI: 10.1371/journal.pone.0201194 PubMed: 30024961
Baquero M et al.. "Insights from a 7-Year Dementia Cohort (VALCODIS): ApoE Genotype Evaluation." Journal of clinical medicine (2024). DOI
López-Lorenzo G et al.. "Monitoring of porcine circovirus type 2 infection through air and surface samples in vaccinated and unvaccinated fattening farms." Transboundary and emerging diseases (2022). DOI
Ballesteros S et al.. "Effects of Video Game Training on Behavioral and Electrophysiological Measures of Attention and Memory: Protocol for a Randomized Controlled Trial." JMIR research protocols (2017). DOI
Ballesteros S et al.. "Effects of multidomain versus single-domain training on executive control and memory in older adults: study protocol for a randomized controlled trial." Trials (2020). DOI
Naranjo JR et al.. "Activating transcription factor 6 derepression mediates neuroprotection in Huntington's Disease." The Journal of clinical investigation (2016). DOI
Ruiz-Marquez E et al.. "Effects of Nonaction Videogames on Attention and Memory in Young Adults." Games for health journal (2019). DOI
Ballesteros S et al.. "Effects of Video Game Training on Measures of Selective Attention and Working Memory in Older Adults: Results from a Randomized Controlled Trial." Frontiers in aging neuroscience (2017). DOI
Prieto A, Mayas J, Ballesteros S. "Alpha and beta band correlates of haptic perceptual grouping: Results from an orientation detection task." PloS one (2018). DOI
Baquero M et al.. "Insights from a 7-Year Dementia Cohort (VALCODIS): ApoE Genotype Evaluation." Journal of clinical medicine (2024). DOI: 10.3390/jcm13164735 PubMed: 39200877
López-Lorenzo G et al.. "Monitoring of porcine circovirus type 2 infection through air and surface samples in vaccinated and unvaccinated fattening farms." Transboundary and emerging diseases (2022). DOI: 10.1111/tbed.14069 PubMed: 33711193
Ballesteros S et al.. "Effects of Video Game Training on Behavioral and Electrophysiological Measures of Attention and Memory: Protocol for a Randomized Controlled Trial." JMIR research protocols (2017). DOI: 10.2196/resprot.6570 PubMed: 28119279
Ballesteros S et al.. "Effects of multidomain versus single-domain training on executive control and memory in older adults: study protocol for a randomized controlled trial." Trials (2020). DOI: 10.1186/s13063-020-04293-3 PubMed: 32410715
Naranjo JR et al.. "Activating transcription factor 6 derepression mediates neuroprotection in Huntington's Disease." The Journal of clinical investigation (2016). DOI: 10.1172/JCI82670 PubMed: 26752648
Ruiz-Marquez E et al.. "Effects of Nonaction Videogames on Attention and Memory in Young Adults." Games for health journal (2019). DOI: 10.1089/g4h.2019.0004 PubMed: 31347931
Ballesteros S et al.. "Effects of Video Game Training on Measures of Selective Attention and Working Memory in Older Adults: Results from a Randomized Controlled Trial." Frontiers in aging neuroscience (2017). DOI: 10.3389/fnagi.2017.00354 PubMed: 29163136
Prieto A, Mayas J, Ballesteros S. "Alpha and beta band correlates of haptic perceptual grouping: Results from an orientation detection task." PloS one (2018). DOI: 10.1371/journal.pone.0201194 PubMed: 30024961
Baquero M et al.. "Insights from a 7-Year Dementia Cohort (VALCODIS): ApoE Genotype Evaluation." Journal of clinical medicine (2024). DOI
López-Lorenzo G et al.. "Monitoring of porcine circovirus type 2 infection through air and surface samples in vaccinated and unvaccinated fattening farms." Transboundary and emerging diseases (2022). DOI
Ballesteros S et al.. "Effects of Video Game Training on Behavioral and Electrophysiological Measures of Attention and Memory: Protocol for a Randomized Controlled Trial." JMIR research protocols (2017). DOI
Ballesteros S et al.. "Effects of multidomain versus single-domain training on executive control and memory in older adults: study protocol for a randomized controlled trial." Trials (2020). DOI
Naranjo JR et al.. "Activating transcription factor 6 derepression mediates neuroprotection in Huntington's Disease." The Journal of clinical investigation (2016). DOI
Ruiz-Marquez E et al.. "Effects of Nonaction Videogames on Attention and Memory in Young Adults." Games for health journal (2019). DOI
Ballesteros S et al.. "Effects of Video Game Training on Measures of Selective Attention and Working Memory in Older Adults: Results from a Randomized Controlled Trial." Frontiers in aging neuroscience (2017). DOI
Prieto A, Mayas J, Ballesteros S. "Alpha and beta band correlates of haptic perceptual grouping: Results from an orientation detection task." PloS one (2018). DOI
Baquero M et al.. "Insights from a 7-Year Dementia Cohort (VALCODIS): ApoE Genotype Evaluation." Journal of clinical medicine (2024). DOI: 10.3390/jcm13164735 PubMed: 39200877
López-Lorenzo G et al.. "Monitoring of porcine circovirus type 2 infection through air and surface samples in vaccinated and unvaccinated fattening farms." Transboundary and emerging diseases (2022). DOI: 10.1111/tbed.14069 PubMed: 33711193
Ballesteros S et al.. "Effects of Video Game Training on Behavioral and Electrophysiological Measures of Attention and Memory: Protocol for a Randomized Controlled Trial." JMIR research protocols (2017). DOI: 10.2196/resprot.6570 PubMed: 28119279
Ballesteros S et al.. "Effects of multidomain versus single-domain training on executive control and memory in older adults: study protocol for a randomized controlled trial." Trials (2020). DOI: 10.1186/s13063-020-04293-3 PubMed: 32410715
Naranjo JR et al.. "Activating transcription factor 6 derepression mediates neuroprotection in Huntington's Disease." The Journal of clinical investigation (2016). DOI: 10.1172/JCI82670 PubMed: 26752648
Ruiz-Marquez E et al.. "Effects of Nonaction Videogames on Attention and Memory in Young Adults." Games for health journal (2019). DOI: 10.1089/g4h.2019.0004 PubMed: 31347931
Ballesteros S et al.. "Effects of Video Game Training on Measures of Selective Attention and Working Memory in Older Adults: Results from a Randomized Controlled Trial." Frontiers in aging neuroscience (2017). DOI: 10.3389/fnagi.2017.00354 PubMed: 29163136
Prieto A, Mayas J, Ballesteros S. "Alpha and beta band correlates of haptic perceptual grouping: Results from an orientation detection task." PloS one (2018). DOI: 10.1371/journal.pone.0201194 PubMed: 30024961
Page auto-generated from NeuroWiki researcher database. Last updated: 2026-03-01.
Page auto-generated from NeuroWiki researcher database. Last updated: 2026-03-01.
The study of Alejandro J. Prieto has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.