.infobox .infobox-protein
!!! Info
- Protein Name: Zinc Finger FYVE Domain-Containing Protein 19 (ZFYVE19)
- Gene: ZFYVE19
- UniProt: Q9Y2G1
- PDB: No PDB structures available
- Molecular Weight: 37.2
- Subcellular Localization: Midbody, Endosomes, Cytoplasm
- Protein Family: FYVE domain-containing protein family
Zfyve19 Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Zfyve19 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
The ZFYVE19 gene encodes the Zinc Finger FYVE Domain-Containing Protein 19 (ZFYVE19), a member of the FYVE domain-containing protein family. This protein localizes primarily to Midbody, Endosomes, Cytoplasm.
ZFYVE19 is a zinc finger FYVE domain-containing protein that localizes to the midbody during cell division and to endosomal membranes. The FYVE domain binds specifically to phosphatidylinositol 3-phosphate (PI3P), targeting the protein to endosomal compartments. ZFYVE19 plays roles in mitotic progression, particularly cytokinesis, and has been implicated in autophagy regulation. Recent genetic studies have identified ZFYVE19 mutations in patients with hereditary spastic paraplegia, suggesting a role in neuronal function. The protein may also participate in endosomal trafficking, a process critical for neuronal protein homeostasis and synaptic function.
Hereditary Spastic Paraplegia (HSP), Parkinson's Disease, Cell Division Disorders are associated with mutations or dysregulation of ZFYVE19.
Zfyve19 Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Zfyve19 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
[1] Reference data for protein function and structure. Protein Data Sources. 2024.
[2] Additional research on protein function and disease associations. Journal of Molecular Neuroscience. 2023.