Ubiquitin is a small conserved protein that marks client proteins for proteasomal degradation, signaling, trafficking, and other quality-control functions.[1][2] It is fundamental to proteostasis and is therefore highly relevant to many neurodegenerative mechanisms.
Ubiquitin connects protein quality control to ubiquitin-proteasome-system, autophagy, and aggregate pathology.[1:1][2:1] It also appears in neuropathologic descriptions of inclusion-bearing disorders, including synucleinopathies and tauopathies.
Overview of the ubiquitin-proteasome system. Current Protocols in Protein Science (2014). ↩︎ ↩︎
Impairment of the ubiquitin-proteasome system in Alzheimer's diseases and other tauopathies. Ageing Research Reviews (2016). ↩︎ ↩︎