Ube2N Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| UBE2N Protein | |
|---|---|
| Protein Name | Ubiquitin-Conjugating Enzyme E2 N (UEV1A) |
| Gene | UBE2N |
| UniProt ID | P61079 |
| PDB ID | 1XWH, 2GMI, 3H3Z |
| Molecular Weight | 17 kDa |
| Subcellular Localization | Cytoplasm, Nucleus |
| Protein Family | Ubiquitin-conjugating enzyme family |
| Aliases | Ubc13, UEV1A, E2-25K |
UBE2N (Ubiquitin-Conjugating Enzyme E2 N), also known as Ubc13 or UEV1A, is a unique E2 ubiquitin-conjugating enzyme that catalyzes the formation of Lys63-linked polyubiquitin chains[1]. Unlike classical E2 enzymes that generate Lys48-linked chains for proteasomal degradation, UBE2N produces non-degradative ubiquitin signals that regulate diverse cellular processes including NF-κB signaling, DNA damage repair, and immune responses[2].
UBE2N has distinctive catalytic properties:
The study of Ube2N Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Deng L, et al. (2000). Activation of the IκB kinase complex by TRAF6. Cell. 103(2):351-361. PMID:11057907 ↩︎
Tokunaga F, et al. (2009). Involvement of linear polyubiquitination of NEMO. Nat Cell Biol. 11(2):123-132. PMID:19136968 ↩︎
Xia ZP, et al. (2009). Direct activation of protein kinases by unanchored polyubiquitin chains. Nature. 461(7260):114-119. PMID:19675569 ↩︎
Hofmann RM, et al. (2009). Non-canonical ubiquitin-binding. Cell Cycle. 8(23):3823-3831. PMID:19888080 ↩︎
Tai HC, et al. (2012). The ubiquitin-proteasome system in neurodegenerative diseases. Neuron. 73(6):1068-1083. PMID:22445338 ↩︎