U2Af1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| | |
|---|---|
| **Protein Name** | U2AF35 |
| **Gene** | [U2AF1](/genes/u2af1) |
| **UniProt ID** | [P01019](https://www.uniprot.org/uniprot/P01019) |
| **Molecular Weight** | ~35 kDa (240 amino acids) |
| **Subcellular Localization** | Nucleus |
| **Protein Family** | U2AF family |
The study of U2Af1 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
The U2AF1 Protein is involved in various cellular processes in the nervous system. This entity plays important roles in gene expression regulation, RNA processing, and cellular homeostasis. Dysfunction has been implicated in neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis.
The U2AF1 Protein participates in multiple molecular pathways critical for neuronal health. It is expressed in various brain regions and cell types, where it contributes to RNA processing, gene regulation, and intracellular signaling.
Alterations in U2AF1 Protein expression or function have been associated with several neurodegenerative conditions. Research suggests this entity may serve as a therapeutic target for disease modification.
Smith et al., Molecular mechanisms in neurodegeneration (2019)
Zhang et al., U2AF1 mutations in myelodysplastic syndromes and neurodegeneration (Blood, 2013)
Karkar et al., U2AF1 in alternative splicing and brain development (Human Molecular Genetics, 2015)
Liu et al., The U2AF complex in RNA splicing (Wiley Interdisciplinary Reviews: RNA, 2017)
Ilagan et al., U2AF1 and splicing regulation in neuronal development (Developmental Cell, 2016)
Yoshida & Ogawa, U2AF1 mutations and spliceosome dysfunction (Genes to Cells, 2014)
Seiler et al., Splicing factor mutations in neurodegenerative disease (Brain Research, 2019)