Thymidine phosphorylase (TYMP) catalyzes the reversible phosphorolysis of thymidine to thymine and 2-deoxyribose-1-phosphate. It also has platelet-derived endothelial cell growth factor activity. TYMP deficiency causes MNGIE, a severe mitochondrial disorder.
Thymidine Phosphorylase Protein is encoded by the TYMP gene. It is a Pyrimidine nucleoside phosphorylase, angiogenesis with a molecular weight of approximately 482 aa. The protein localizes to Cytoplasm, Extracellular.
The Thymidine Phosphorylase Protein contains characteristic domains for its function as a Pyrimidine nucleoside phosphorylase, angiogenesis. Structural information is available from UniProt and the PDB.
Thymidine phosphorylase (TYMP) catalyzes the reversible phosphorolysis of thymidine to thymine and 2-deoxyribose-1-phosphate. It also has platelet-derived endothelial cell growth factor activity. TYMP deficiency causes MNGIE, a severe mitochondrial disorder.
Dysfunction of Thymidine Phosphorylase Protein has been implicated in several neurodegenerative diseases:
Research into therapeutic modulation of Thymidine Phosphorylase Protein includes: