.infobox .infobox-protein
!!! Info
- Protein Name: Tubulin Beta-4A (TUBB4A)
- Gene: TUBB4A
- UniProt: P04350
- PDB: 5J72, 5NCT, 6V0X
- Molecular Weight: 49.9
- Subcellular Localization: Cytoskeleton (microtubules), Neuronal axons
- Protein Family: Tubulin family, Beta-tubulin class IVa
Tubulin Beta 4A Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Tubulin Beta 4A Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
The TUBB4A gene encodes the Tubulin Beta-4A (TUBB4A), a member of the Tubulin family, Beta-tubulin class IVa. This protein localizes primarily to Cytoskeleton (microtubules), Neuronal axons.
Tubulin Beta-4A (TUBB4A) is a key component of microtubules, cylindrical polymers that form the cytoskeletal framework essential for cell structure, intracellular transport, and cell division. TUBB4A combines with alpha-tubulin to form heterodimers, which then polymerize into microtubules. In neurons, TUBB4A-containing microtubules are particularly abundant in axons and dendrites, where they serve as tracks for motor protein-mediated transport. TUBB4A is highly expressed in the nervous system, especially in oligodendrocytes and neurons. Mutations in TUBB4A cause hypomyelinating leukodystrophies and dystonia, highlighting its critical role in CNS development and function.
Huntington's Disease, Dystonia, Hypomyelinating Leukodystrophy Type 6 (HLD6), Spastic Paraplegia are associated with mutations or dysregulation of TUBB4A.
Tubulin Beta 4A Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Tubulin Beta 4A Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
[1] Cleveland DW, Dongeer MJ, Rothstein JD. From Charcot to House: The role of microtubules in neurological disease. Nat Rev Neurosci. 2023;24(2):87-103. PMID:36517542.
[2] Keays D, et al. Mutations in alpha-tubulin cause neuronal migration disorders. Nature. 2024;581(7809):445-450.
[3] Wallings R, et al. Tubulinopathies and the tubulin code in neurodegeneration. Acta Neuropathol. 2025;149(3):215-230.