Thymidine kinase 2 (TK2) is a mitochondrial enzyme that catalyzes the phosphorylation of thymidine, deoxyuridine, and deoxycytidine. It is essential for maintaining mitochondrial DNA (mtDNA) pools through the nucleotide salvage pathway. TK2 deficiency causes mitochondrial DNA depletion syndrome with progressive muscle weakness.
Thymidine Kinase 2 Protein is encoded by the TK2 gene. It is a Mitochondrial thymidine kinase, nucleotide metabolism with a molecular weight of approximately 265 aa. The protein localizes to Mitochondria.
The Thymidine Kinase 2 Protein contains characteristic domains for its function as a Mitochondrial thymidine kinase, nucleotide metabolism. Structural information is available from UniProt and the PDB.
Thymidine kinase 2 (TK2) is a mitochondrial enzyme that catalyzes the phosphorylation of thymidine, deoxyuridine, and deoxycytidine. It is essential for maintaining mitochondrial DNA (mtDNA) pools through the nucleotide salvage pathway. TK2 deficiency causes mitochondrial DNA depletion syndrome with progressive muscle weakness.
Dysfunction of Thymidine Kinase 2 Protein has been implicated in several neurodegenerative diseases:
Research into therapeutic modulation of Thymidine Kinase 2 Protein includes: