Ribosomal Protein S14 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
.infobox .infobox-protein
{
float: right;
width: 300px;
padding: 10px;
background: #f8f9fa;
border: 1px solid #ddd;
border-radius: 4px;
margin: 10px;
}
.infobox .infobox-protein th
{
background: #28a745;
color: white;
padding: 8px;
}
.infobox .infobox-protein td
{
padding: 6px;
}
|+ **Ribosomal Protein S14**
! Protein Name
| Ribosomal Protein S14
! Gene
| [RPS14](/genes/rps14)
! UniProt ID
| [P62263](https://www.uniprot.org/uniprot/P62263)
! PDB IDs
| 4V88, 4V89
! Molecular Weight
| 16.1 kDa
! Subcellular Localization
| Cytoplasm; Ribosome
! Protein Family
| Ribosomal protein S14 family
Ribosomal Protein S14 (RPS14) is a protein involved in protein synthesis and ribosome function. It is located in the cytoplasm and participates in critical cellular pathways.
RPS14 binds to 18S rRNA and is essential for 40S subunit assembly.
RPS14 is a component of the 40S ribosomal subunit. Mutations in RPS14 cause Diamond-Blackfan anemia and affect erythropoiesis.
RPS14 mutations cause Diamond-Blackfan anemia type I. May affect neuronal survival.
No current therapeutic approaches.
The study of Ribosomal Protein S14 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
- De Keersmaecker K et al. (2005) RPS14 and Diamond-Blackfan anemia. Blood 106(5):1730-1736. PMID: 15914561
- Gazda HT et al. (2008) RPS14 mutations in DBA. Blood 112(10):3842-3852. PMID: 18660419
- Narla A et al. (2011) Ribosomal proteins in disease. Oncogene 30(6):641-652. PMID: 21042281
- McCann KL et al. (2015) Ribosome biogenesis. Semin Cell Dev Biol 41:23-32. PMID: 25662506
- Yelick PC et al. (2015) Ribosomal proteins in development. Wiley Interdiscip Rev RNA 6(5):517-532. PMID: 26105199
- Chen J et al. (2017) Ribosomal proteins in neuronal function. Mol Neurobiol 54(10):7922-7933. PMID: 27975156
- Mills EW et al. (2016) Ribosomal proteins in memory. Learn Mem 23(12):719-732. PMID: 27840074
- Warner JR et al. (2001) The ribosome. Science 293(5538):1976-1977. PMID: 11481458
- De Keersmaecker K et al. (2005) RPS14 and Diamond-Blackfan anemia. Blood 106(5):1730-1736. PMID: 15914561
- Gazda HT et al. (2008) RPS14 mutations in DBA. Blood 112(10):3842-3852. PMID: 18660419
- Narla A et al. (2011) Ribosomal proteins in disease. Oncogene 30(6):641-652. PMID: 21042281
- McCann KL et al. (2015) Ribosome biogenesis. Semin Cell Dev Biol 41:23-32. PMID: 25662506
- Yelick PC et al. (2015) Ribosomal proteins in development. Wiley Interdiscip Rev RNA 6(5):517-532. PMID: 26105199
- Chen J et al. (2017) Ribosomal proteins in neuronal function. Mol Neurobiol 54(10):7922-7933. PMID: 27975156
- Mills EW et al. (2016) Ribosomal proteins in memory. Learn Mem 23(12):719-732. PMID: 27840074
- Warner JR et al. (2001) The ribosome. Science 293(5538):1976-1977. PMID: 11481458