Rgs14 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
RGS14 is a protein that plays a critical role in neurodegenerative disease. It is located on chromosome 5q31.2 and catalogued as NCBI Gene ID 10636.
RGS14 is a regulator of G protein signaling that integrates neuronal signaling pathways.
RGS14 (Regulator of G Protein Signaling 14) is a unique scaffold protein that integrates G protein and MAPK signaling in hippocampal learning and memory.
| Attribute | Value |
|---|---|
| Protein Name | Regulator of G Protein Signaling 14 |
| Gene | RGS14 |
| UniProt ID | Q9Y2H9 |
| Molecular Weight | ~66 kDa |
| Subcellular Localization | Cytoplasm, dendritic spines |
| Protein Family | RGS family (RGS12 subfamily) |
RGS14 contains multiple functional domains:
This combination allows RGS14 to function as a molecular hub integrating G protein and Ras-MAPK signaling.
RGS14 integrates multiple signaling pathways:
Specifically enriched in CA2 pyramidal neurons where it regulates synaptic plasticity and social memory.
Alzheimer's Disease: Impaired hippocampal plasticity contributes to cognitive deficits. RGS14 expression altered in AD hippocampus.
Schizophrenia: Dysregulated synaptic function in hippocampus due to altered RGS14 signaling.
Intellectual Disability: Developmental abnormalities from impaired neuronal signaling integration.
Migraine: Vascular signaling dysregulation through G protein pathway effects.
RGS14 targeting approaches:
The study of Rgs14 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.