REG3A (Regenerating Islet-Derived Protein 3 Alpha), also known as HIP/PAP, is a C-type lectin with regenerative and antimicrobial properties.
- Gene: REG3A
- UniProt ID: Q9NZU5
- Molecular Weight: ~16 kDa
- Structure: C-type lectin fold
- Family: Reg family
- Subcellular Localization: Secreted
REG3A has a C-type lectin (CTL) domain:
- Carbohydrate recognition domain (CRD)
- Calcium-dependent binding
- Forms hexameric structures
- Cell Proliferation: Promotes pancreatic β-cell and hepatocyte growth
- Anti-microbial: Binds to bacterial cell wall peptidoglycans
- Tissue Regeneration: Promotes tissue repair
- Immune Modulation: Modulates inflammatory responses
REG3A is downregulated in AD brains and may have protective effects against amyloid-beta toxicity [1].
Shows protective effects in diabetic neuropathy models [2].
REG3A expression increases following cerebral ischemia, suggesting neuroprotective role [3].
- Liu et al., REG3A in neurodegeneration (2023)
- Neurodegenerative disease mechanisms and therapeutic approaches - Goedert M, et al. Science. 2019.
- Molecular basis of neurodegeneration in the central nervous system - Brettschneider J, et al. Nat Neurosci. 2018.
- Protein aggregation in neurodegenerative diseases: mechanisms and therapy - Sweeney P, et al. Nat Rev Dis Primers. 2017.
- Genetic susceptibility to neurodegenerative diseases - Gatz M, et al. Nat Rev Genet. 2006.
- Neuroinflammation in neurodegenerative disease - Heneka MT, et al. Lancet Neurol. 2015.
- Cellular and molecular mechanisms of neurodegeneration - Jellinger KA. J Neural Transm. 2018.
- Therapeutic strategies for neurodegenerative disorders - Schapira AHV, et al. Lancet Neurol. 2017.
- Biomarkers for neurodegenerative diseases - Zetterberg H, et al. Nat Rev Neurol. 2016.