| RAB3B Protein | |
|---|---|
| Protein Name | RAB3B |
| Gene | RAB3B |
| UniProt ID | Q8WUD1 |
| Molecular Weight | 25 kDa |
| Subcellular Localization | Synaptic vesicles, secretory granules |
| Protein Family | RAB GTPase family |
RAB3B is a small GTPase belonging to the RAB family of proteins, which regulate vesicular trafficking in eukaryotic cells. RAB3B is particularly involved in synaptic vesicle trafficking and neurotransmitter release, functioning as a key regulator of exocytosis in neurons. It plays essential roles in synaptic vesicle priming, fusion, and recycling, making it crucial for normal synaptic transmission. In neurodegenerative diseases, alterations in RAB3B expression and function may contribute to synaptic dysfunction, a hallmark of conditions like Alzheimer's and Parkinson's disease.
RAB3B is a small GTPase:
Like other RAB3 isoforms, RAB3B cycles between active (GTP) and inactive (GDP) states.
RAB3B regulates synaptic vesicle trafficking:
RAB3B is expressed in specific neuronal populations including hippocampal mossy fiber terminals.