Psma3 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Protein Name | Proteasome Subunit Alpha Type 3 |
| Gene | PSMA3 |
| UniProt ID | P25788 |
| PDB ID | 5MX3 |
| Molecular Weight | 28.1 kDa |
| Subcellular Localization | Cytoplasm, Nucleus |
| Protein Family | Proteasome alpha subunit family |
PSMA3 PROTEIN is a gene/protein encoding a key neuronal protein involved in synaptic function, signal transduction, and cellular homeostasis. Dysfunction of PSMA3 PROTEIN is associated with neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and related disorders.
PSMA3 (28.1 kDa) is a component of the outer α-ring of the 20S proteasome. It contains the characteristic N-terminal threonine nucleophile and contributes to the structural architecture of the proteasome gate.
The proteasome α-ring (PSMA1-7) controls substrate entry, while the β-ring (PSMB1-7) contains the proteolytic sites (β1, β2, β5) with caspase-like, trypsin-like, and chymotrypsin-like activities.
PSMA3 functions in the ubiquitin-proteasome system:
The study of Psma3 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.