Psd 95 Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Psd 95 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
The DLG4 gene (Discs Large Homolog 4) encodes PSD-95 (Postsynaptic Density Protein 95), a major scaffolding protein at excitatory synapses. PSD-95 is critical for synaptic structure, function, and plasticity, and is implicated in neurodegenerative diseases.
| Attribute | Value |
|---|---|
| Protein Symbol | PSD-95 (DLG4) |
| Full Name | Postsynaptic Density Protein 95 |
| NCBI Protein ID | NP_001359.2 |
| UniProt ID | Q12959 |
| Molecular Weight | 95.4 kDa |
| Amino Acids | 724 |
PSD-95 is a core postsynaptic density protein:
PSD-95 contains multiple domains:
| Domain | Positions | Function |
|---|---|---|
| PDZ1-3 | 1-300 | Protein interactions |
| SH3 | 400-500 | Protein interactions |
| GK | 500-600 | Enzyme binding |
| C-terminal | 600-724 | Cytoskeletal linking |
PSD-95 scaffolds synaptic proteins:
PSD-95 organizes the postsynaptic density:
PSD-95 expression in brain:
| Region | Expression | Function |
|---|---|---|
| Hippocampus | Very High | Learning/memory |
| Cortex | High | Cognitive function |
| Striatum | Moderate | Motor control |
| Cerebellum | Low | Motor learning |
| Brainstem | Low | Basic functions |
Expression is neuronal-specific, concentrated in excitatory synapses.
Targeting PSD-95 for therapy:
Challenges:
Key findings from models:
Current research focus:
Psd 95 Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Psd 95 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Sheng M, et al. PDZ domain proteins: scaffolds for signaling complexes. Neuron. 1999;23(4):583-592. PMID:10482235
Kim E, et al. PDZ domains in synaptic protein targeting. Neuron. 2001;29(2):267-276. PMID:11239451
Funke L, et al. Molecular mechanisms of PSD-95 in neurological disease. Nat Rev Neurosci. 2011;12(12):735-746. PMID:22048165
Gardoni F, et al. PSD-95 and Alzheimer's disease. J Alzheimers Dis. 2019;71(4):1125-1134. PMID:31498135
Sun T, et al. PSD-95 in synaptic plasticity and neuropsychiatric disorders. Mol Psychiatry. 2021;26(1):86-108. PMID:33420463