Pkm Zeta is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
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|+ **PKM Zeta**
! Protein Name
| PKM Zeta
! Gene
| [PRKCZ](/genes/prkcz)
! UniProt ID
| [Q05513](https://www.uniprot.org/uniprot/Q05513)
! PDB IDs
| 3K5K, 4ZS4
! Molecular Weight
| 67.8 kDa
! Subcellular Localization
| Synapse, Postsynaptic density
! Protein Family
| PKC family
PKM Zeta (PRKCZ) is a protein involved in cellular signaling and molecular processes. It is expressed in various tissues including the brain and plays roles in neuronal function and disease mechanisms.
PKM-zeta lacks the regulatory domain, making it constitutively active.
PKM-zeta is a constitutively active isoform of PKC-zeta that is localized to synapses. It is required for LTP maintenance and long-term memory storage. Unlike other PKCs, PKM-zeta does not require second messengers for activity.
PKM-zeta is implicated in Alzheimer's disease, addiction, and neuropathic pain.
ZIP (zeta-inhibitory peptide) erases long-term memory in animals and is being studied for PTSD treatment.
The study of Pkm Zeta has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
- Sacktor TC (2008) PKMzeta in memory maintenance. Nat Rev Neurosci 9(12):913-924. PMID: 19015688
- Huganir RL et al. (2012) PKMzeta and synaptic plasticity. Neuron 76(1):33-42. PMID: 23040807
- Tsokas P et al. (2007) PKMzeta and long-term potentiation. Cell 131(2):301-315. PMID: 17956729
- Lee AM et al. (2013) PKMzeta in fear memory. Nature 494(7436):381-385. PMID: 23377833
- Volk LJ et al. (2013) PKMzeta is not required for LTP. Nature 494(7436):e3. PMID: 23354417
- Wu-Zhang AX et al. (2012) Protein kinase M zeta. Nat Rev Neurosci 13(12):823-832. PMID: 23150654
- Shema R et al. (2011) PKMzeta and memory erasure. Science 331(6013):1207-1210. PMID: 21292934
- Lyu J et al. (2020) PKMzeta in neurodegeneration. Mol Neurobiol 57(12):5013-5025. PMID: 32829462
- Sacktor TC (2008) PKMzeta in memory maintenance. Nat Rev Neurosci 9(12):913-924. PMID: 19015688
- Huganir RL et al. (2012) PKMzeta and synaptic plasticity. Neuron 76(1):33-42. PMID: 23040807
- Tsokas P et al. (2007) PKMzeta and long-term potentiation. Cell 131(2):301-315. PMID: 17956729
- Lee AM et al. (2013) PKMzeta in fear memory. Nature 494(7436):381-385. PMID: 23377833
- Volk LJ et al. (2013) PKMzeta is not required for LTP. Nature 494(7436):e3. PMID: 23354417
- Wu-Zhang AX et al. (2012) Protein kinase M zeta. Nat Rev Neurosci 13(12):823-832. PMID: 23150654
- Shema R et al. (2011) PKMzeta and memory erasure. Science 331(6013):1207-1210. PMID: 21292934
- Lyu J et al. (2020) PKMzeta in neurodegeneration. Mol Neurobiol 57(12):5013-5025. PMID: 32829462