Pp1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Protein Phosphatase 1 | |
|---|---|
| Protein Name | PP1 |
| Gene | PPP1CA |
| UniProt ID | P62136 |
| PDB ID | 1J7O, 3N7U |
| Molecular Weight | 37 kDa |
| Subcellular Localization | Cytoplasm, Nucleus |
| Protein Family | PP1 family, Ser/Thr protein phosphatase |
| Associated Diseases | Alzheimer's Disease, Parkinson's Disease |
PP1 is a metalloenzyme with an active site containing two metal ions (manganese):
The enzyme interacts with over 200 regulatory proteins that target it to specific substrates and cellular locations.
PP1 regulates numerous neuronal processes:
In Alzheimer's Disease:
In Parkinson's Disease:
PP1 modulators are being investigated:
The study of Pp1 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
This section provides background information on the gene/protein and its role in the nervous system.
This overview section needs to be expanded with relevant scientific information from peer-reviewed sources.