| POLD1 | |
|---|---|
| Gene | POLD1 |
| UniProt | P28340 |
| PDB | 1TAQ, 3IAY, 5EXR |
| Mol. Weight | 123 kDa |
| Localization | Nucleus, Mitochondria |
| Family | DNA polymerase B family |
| Diseases | Alzheimer's Disease, Parkinson's Disease, MDDP Syndrome |
Pold1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
POLD1 is a protein encoded by the POLD1 gene. It belongs to the DNA polymerase B family family and has a molecular weight of approximately 123 kDa. This protein is localized to Nucleus, Mitochondria and plays a significant role in the pathogenesis of Alzheimer's Disease, Parkinson's Disease, MDDP Syndrome.
POLD1 has been characterized structurally through X-ray crystallography and cryo-EM. Available PDB structures include: 1TAQ, 3IAY, 5EXR.
The protein's three-dimensional structure can also be explored via the AlphaFold Protein Structure Database.
Under physiological conditions, POLD1 performs essential functions in the nervous system. It is primarily found in Nucleus, Mitochondria and contributes to normal cellular homeostasis, signaling, and neuronal function.
POLD1 is implicated in the following neurodegenerative conditions:
Misfolding, aggregation, or dysfunction of POLD1 contributes to neuronal damage through various mechanisms including proteotoxic stress, disrupted cellular signaling, and neuroinflammation.
POLD1 represents an important therapeutic target. Multiple drug development programs are exploring strategies to modulate its function, reduce toxic forms, or enhance clearance mechanisms.
Publication list pending enrichment from PubMed.
The study of Pold1 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Page auto-generated from NeuroWiki protein database. Last updated: 2026-02-26.