| Protocadherin 15 | |
|---|---|
| Gene | PCDH15 |
| UniProt | Q9P1E5 |
| PDB | N/A |
| Mol. Weight | 210 kDa |
| Localization | Cell membrane |
| Family | Cadherin superfamily |
| Diseases | Usher Syndrome, Hearing Loss |
Protocadherin 15 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Protocadherin 15 is a protein encoded by the PCDH15 gene. It belongs to the Cadherin superfamily family and has a molecular weight of approximately 210 kDa. This protein is localized to Cell membrane and plays a significant role in the pathogenesis of Usher Syndrome, Hearing Loss.
Protocadherin 15 has been characterized structurally through X-ray crystallography and cryo-EM. Available PDB structures include: No structures deposited.
The protein's three-dimensional structure can also be explored via the AlphaFold Protein Structure Database.
Under physiological conditions, Protocadherin 15 performs essential functions in the nervous system. It is primarily found in Cell membrane and contributes to normal cellular homeostasis, signaling, and neuronal function.
Protocadherin 15 is implicated in the following neurodegenerative conditions:
Misfolding, aggregation, or dysfunction of Protocadherin 15 contributes to neuronal damage through various mechanisms including proteotoxic stress, disrupted cellular signaling, and neuroinflammation.
Protocadherin 15 represents an important therapeutic target. Multiple drug development programs are exploring strategies to modulate its function, reduce toxic forms, or enhance clearance mechanisms.
Publication list pending enrichment from PubMed.
The study of Protocadherin 15 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Page auto-generated from NeuroWiki protein database. Last updated: 2026-02-26.