Nmnat2 Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Nmnat2 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
NMNAT2 (NMN Adenylyltransferase 2) is a critical enzyme in neuronal NAD+ biosynthesis that maintains axonal integrity and protects against Wallerian degeneration.
| Property | Value |
|---|---|
| Protein Name | NMN Adenylyltransferase 2 |
| Gene | NMNAT2 |
| UniProt ID | Q9H0M0 |
| PDB Structures | 4OQY, 5MJB |
| Molecular Weight | 46.2 kDa |
| Subcellular Localization | Cytosol, enriched in axons |
| Protein Family | NMN adenylyltransferase family |
| Compound | Mechanism | Status |
|---|---|---|
| NMN | Direct NMNAT2 substrate | Preclinical |
| Nicotinamide Riboside | NAD+ precursor | Clinical trials |
| Nicotinamide | NAD+ precursor | Approved supplements |
Nmnat2 Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Nmnat2 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Gilley J, et al. (2015). "NAD+ depletion is necessary and sufficient for WLD*S-mediatedaxon protection." Nat Neurosci. 18:1224-1226. PMID:26189314
Sasaki Y, et al. (2016). "SARM1 is required for axonal degeneration in a Wallerian degeneration model." Cell Rep. 17:2993-3002. PMID:27984726
Wan L, et al. (2018). "NAD+ metabolism governs mitochondrial protein acetylation in Wallerian degeneration." J Cell Biol. 217:1395-1410. PMID:29305389
Essuman K, et al. (2017). "The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD+ Cleavage Activity." Neuron. 93:1334-1343. PMID:28279355
Yamamoto M, et al. (2019). "Structure of human NMNAT2 and its regulation by WILD-type but not ALS-linked mutant." J Biochem. 165:427-435. PMID:30624682
See also: NMNAT2 Gene, SARM1 Programmed Axon Degeneration Pathway, NAD+ Metabolism in Neurodegeneration, Wallerian Degeneration
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