Nf Κb P100 P52 Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Nf Κb P100 P52 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| NF-κB p100/p52 Protein | |
|---|---|
| Protein Name | NF-κB p100/p52 Protein |
| Gene | NFKB2 |
| UniProt ID | Q12986 |
| PDB IDs | 1A3Q, 1XMP |
| Molecular Weight | 100 kDa (p100), 52 kDa (p52) |
| Subcellular Location | Nucleus, Cytoplasm |
| Protein Family | NF-κB transcription factors |
NF-κB p100/p52 Protein is a NF-κB transcription factors. The protein is involved in signal transduction and contains domains typical of NF-κB pathway components.
NFKB2 encodes p100, which is processed to p52. p52 forms heterodimers with RELB in the non-canonical NF-κB pathway. This pathway is activated by specific stimuli including lymphotoxin, BAFF, and CD40 ligand. The non-canonical pathway regulates B cell maturation, lymphoid organogenesis, and immune cell survival.
p100 mutations cause ankylosing spondylitis and related autoimmune diseases. Dysregulated non-canonical NF-κB signaling is implicated in neurodegeneration.
Experimental agents targeting non-canonical NF-κB pathway.
Nf Κb P100 P52 Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Nf Κb P100 P52 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
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