Neurabin-1, also known as Neural Tissue-Specific F-Actin Binding Protein (NAB1) or PPP1R18, is a 784 amino acid postsynaptic scaffolding protein enriched in dendritic spines and excitatory synapses. Neurabin-1 plays essential roles in synaptic formation, maintenance, and plasticity by organizing the actin cytoskeleton and anchoring synaptic proteins. The protein is highly expressed in the brain and has been implicated in neurodegenerative diseases and psychiatric disorders.
| Neurabin-1 | |
|---|---|
| Protein Name | Neurabin-1 |
| Gene | PPP1R18 |
| UniProt ID | Q9C0B1 |
| PDB Structures | Not determined |
| Molecular Weight | 88 kDa |
| Subcellular Localization | Dendritic spines, Postsynaptic density |
| Protein Family | Neurabin family |
Neurabin-1 is a neuron-specific protein that was first identified as a binding partner for protein phosphatase 1 (PP1) and as an F-actin binding protein. The protein contains multiple domains including an actin-binding domain, a PP1-binding domain, and PDZ-binding motifs, enabling it to serve as a molecular scaffold that connects the actin cytoskeleton with synaptic signaling machinery. Neurabin-1 is critical for spine formation and synaptic plasticity.
PPP1R18 encodes neurabin-1, which is expressed exclusively in neural tissue. Studies have shown that neurabin-1 is essential for proper brain development and synaptic function. Neurabin-1 knockout mice display abnormal synaptic morphology and deficits in learning and memory. The protein's role in organizing postsynaptic structures and regulating actin dynamics makes it relevant to understanding synaptic dysfunction in neurodegenerative diseases. Additionally, neurabin-1 has been implicated in psychiatric disorders including schizophrenia and bipolar disorder.
Neurabin-1 is an 88 kDa protein belonging to the Neurabin family.
Neurabin-1 is a postsynaptic scaffold protein that organizes actin cytoskeleton and synaptic proteins. It regulates spine formation, synaptic plasticity, and anchors protein phosphatase 1 at postsynaptic sites.
Neurabin-1 in neurodegeneration:
Altered expression in Alzheimer's Disease
Links to synaptic dysfunction
Associated with psychiatric disorders
Alzheimer's Disease, Schizophrenia
Further research is needed to identify key publications for this protein.