Ndufs4 Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Ndufs4 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
NDUFS4 Protein
| Protein Name | NDUFS4 Protein |
| Gene | NDUFS4 |
| UniProt ID | O43920 |
| PDB IDs | 6RCQ |
| Molecular Weight | 17 kDa |
| Subcellular Localization | Mitochondrial Matrix |
| Protein Family | NADH Dehydrogenase Complex I Subunits |
NDUFS4 protein belongs to the NADH Dehydrogenase Complex I Subunits. The protein localizes to Mitochondrial Matrix.
NDUFS4 is a accessory subunit of mitochondrial Complex I that is required for proper assembly and stability of the complex.
Loss-of-function mutations in NDUFS4 cause severe mitochondrial Complex I deficiency leading to Leigh syndrome, characterized by progressive neurodegeneration in the brainstem.
No specific therapies; supportive care and metabolic supplements are used.
Ndufs4 Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Ndufs4 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.