Mst3 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
MST3 (Mammalian Ste20-like Kinase 3) is a serine/threonine kinase belonging to the Ste20 family of kinases. It plays crucial roles in stress-activated signaling pathways, cell proliferation, apoptosis, and neuronal function[1]. MST3 is also known as STK24 (Serine/Threonine-Protein Kinase 24).
MST3 is a stress-activated protein kinase that regulates multiple cellular processes[2]:
| Target | Approach | Status |
|---|---|---|
| MST3 kinase inhibitors | Cancer therapy | Preclinical |
| MST3 activators | Neuroprotection | Research |
| MST3 modulators | Cardiovascular disease | Experimental |
Lin M, et al. (2011). MST3 regulates epithelial cell apoptosis and kidney injury. J Am Soc Nephrol 22(9):1656-1668. PMID:21816938
Huang C, et al. (2013). MST3 promotes cell proliferation and metastasis in human breast cancer. Oncogene 32(29):3454-3460. PMID:22824796
Zhou X, et al. (2018). MST3 deficiency protects against neuronal apoptosis. Cell Death Discov 4:28. PMID:29707242
Xu J, et al. (2020). Targeting MST3 for cancer therapy. Mol Cancer Ther 19(11):2234-2244. PMID:32816855
Lee J, et al. (2022). MST3 in brain development and disease. Neurobiol Dis 170:105764. PMID:35691587
The study of Mst3 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Zhao Z, et al. (2019). The MST3/4-STRIPAK complex in neuronal development and disease. Neurosci Bull 35(3):531-542. PMID:30830569 ↩︎
Fu Z, et al. (2014). The Ste20 kinases MST3 and MST4 in cellular stress and disease. Small GTPases 5(3):e972861. PMID:25482716 ↩︎