Ms4A3 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
{{infobox .infobox-protein}}
| Property | Value |
|---|---|
| Protein Name | Membrane Spanning 4-Domains A3 |
| Gene | MS4A3 |
| UniProt ID | Q9H5Y4 |
| Molecular Weight | ~25 kDa |
| Subcellular Localization | Plasma membrane, endoplasmic reticulum |
| Protein Family |
This page provides comprehensive information about the subject's role in neurodegenerative diseases. The subject participates in various molecular pathways and cellular processes relevant to Alzheimer's disease, Parkinson's disease, and related conditions.
MS4A (Tetraspanin) family |
| Expression | Hematopoietic cells, brain |
MS4A3 (Membrane Spanning 4-Domains A3) is a member of the MS4A family, which includes multiple tetraspanin-like proteins. MS4A3 contains four transmembrane domains with intracellular N- and C-termini, forming a characteristic structure that allows interaction with various signaling complexes [1].
Signal Transduction: Modulates calcium signaling and receptor clustering
Immune Function: Regulates mast cell and basophil activation
Membrane Organization: Organizes signaling complexes in lipid rafts
Hematopoiesis: Involved in differentiation of hematopoietic lineages
The study of Ms4A3 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.